Top1 - topoisomerase (DNA) I Gene

Also Known as Top-1; D130064I21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21969

About Top1

Chromosome 2: 160,487,808-160,564,684 forward strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues.

Summary

Enables DNA Topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within DNA replication; DNA topological change; and embryonic cleavage. Located in cytoplasm; nucleus; and perikaryon. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA Topoisomerase I). [provided by Alliance of Genome Resources, Apr 2022]

Top1 Products (4)

mRNA Protein Name
NM_009408.3 NP_033434.2 DNA topoisomerase 1 isoform 1
NM_001413149.1 NP_001400078.1 DNA topoisomerase 1 isoform 3
NM_001413148.1 NP_001400077.1 DNA topoisomerase 1 isoform 2
NM_001413150.1 NP_001400079.1 DNA topoisomerase 1 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
IDA: Inferred from direct assay
7842491 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
11756244 MGI
acts upstream of or within DNA topological change IDA
IDA: Inferred from direct assay
7842491 MGI
acts upstream of or within embryonic cleavage IMP
IMP: Inferred from mutant phenotype
8943335 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16261531 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
9094096 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8943335 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
16261531 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top1 Protein Structure

Topoisomer_IB_N_htopoI_like

Topoisomer_IB_N_htopoI_like: cd03488 (217 - 431)

TOPEUc

TOPEUc: smart00435 (361 - 738)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 1

  • DNA topoisomerase I

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16560 Camptothecin 99.77% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-171689 Puxitatug samrotecan Inhibitor 98.51% Phase 3
HY-U00248A LMP744 hydrochloride Inhibitor 99.08% Phase 2
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-171124 Tilatamig samrotecan Inhibitor 95.26% Phase 1
HY-18350 Indimitecan Inhibitor 98.30% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990940 Precemtabart Inhibitor 99.00% Phase 3

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164734 Raludotatug Deruxtecan 99.29% Unkown
HY-148819A NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Inhibitor 98.46% Unkown
HY-148819 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Inhibitor 98.71% Unkown
HY-163099 P5(PEG24)-VC-PAB-Exatecan 99.74% Unkown
HY-153278 Q901 Inhibitor 98.38% Unkown
HY-U00248 LMP744 Inhibitor 98.33% Unkown
HY-153278A Q901 TFA Inhibitor / Unkown
HY-160005 LMP517 Inhibitor 99.20% Unkown
HY-175203 Topi MF-6 Inhibitor 99.79% Unkown
HY-W008874 meso-Tetra(4-pyridyl)porphine Inhibitor 98.0% Unkown
HY-N0114A (±)-Evodiamine 99.74% Unkown
HY-126142 Top1 inhibitor 1 Inhibitor 99.67% Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118942 Topovale Inhibitor 99.94% Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144794 EGFR-IN-46 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-159935 Top1-IN-2 Inhibitor / Unkown
HY-161957 Top1/2-IN-1 Inhibitor / Unkown
HY-16560B (R)-Camptothecin Control / Unkown
HY-178036 ZM484 Inhibitor / Unkown
HY-180555 SN38-(PEG)2-Pom-α Activator / Unkown
HY-181080 TOP1/TDP1-IN-1 / Unkown
HY-18350A Indimitecan hydrochloride Inhibitor / Unkown
HY-184245 Hsp90-IN-48 Inhibitor / Unkown
HY-184984 SN-38-A2 Degrader / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990947 Tilatamig Inhibitor 99.99% Unkown
HY-P991164 Torvutatug Inhibitor 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top1 NCBI NCBI:7150