Il5 - interleukin 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24497

About Il5

Primary_assembly 10: 37,874,342-37,877,213 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 91 orthologues and is associated with 51 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5). [provided by Alliance of Genome Resources, Apr 2022]

Il5 Products (1)

mRNA Protein Name
NM_021834.1 NP_068606.1 interleukin-5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10331007 RGD
enables cytokine activity IMP
IMP: Inferred from mutant phenotype
1653053 RGD
enables interleukin-5 receptor binding IDA
IDA: Inferred from direct assay
10331007 RGD
enables interleukin-5 receptor binding IMP
IMP: Inferred from mutant phenotype
10867506 RGD
Biological Process GO Annotation Evidence References Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
11335106 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
10867506 RGD
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
10529595 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10331007 RGD
involved in positive regulation of eosinophil differentiation IDA
IDA: Inferred from direct assay
10529595 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
10867506 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20232121 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il5 Protein Structure

IL5

IL5: pfam02025 (19 - 130)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

interleukin-5

  • B-cell growth factor II

  • BCGF-II

  • IL-5

  • Interleukin 5 (colony-stimulating factor, eosinophil)

  • T-cell replacing factor

  • TRF

  • cytotoxic T-lymphocyte inducer

  • eosinophil differentiation factor

Recombinant Il5 Proteins

Cat. No. Product Name Accession Purity
HY-P7102 IL-5 Protein, Rat Q08125 (M20-V132) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7102A IL-5 Protein, Rat (CHO) Q08125 (M20-V132) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17002 Suplatast (Tosilate) Inhibitor 99.67% Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9945 Mepolizumab 99.4% Unkown
HY-P9923 Benralizumab 99.1% Unkown
HY-P9949 Reslizumab Antagonist 99.4% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-137131 DC-Chol hydrochloride 99.95% Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99850 Depemokimab Inhibitor 95.24% Phase 3
HY-P99371 Lirentelimab Inducer 99.91% Phase 3
HY-P991599 SHR-1703 Inhibitor / Phase 3
HY-P991266 SM-17 Inhibitor 96.98% Phase 2
HY-P991633 TQC2938 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19969 YM-90709 Inhibitor 99.20% Unkown
HY-N6013 Aloin (mixture of A&B) 99.36% Unkown
HY-NP159 House Dust Mite Extract, from D.farinae Activator / Unkown
HY-N1938 D(+)-Raffinose pentahydrate ≥98.0% Unkown
HY-N0646 Silydianin 99.71% Unkown
HY-N8309 Luteolin-4'-O-glucoside Inhibitor 99.36% Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor 99.35% Unkown
HY-110295 SPL-334 Inhibitor 99.6% Unkown
HY-19486 UR-1505 Inhibitor 99.97% Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-W585843 1,1′-Ethylidenebis[L-tryptophan] Activator 96.04% Unkown
HY-106979 Olcorolimus Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-175876 ADAM17-IN-1 Inhibitor / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-19472 RWJ-58643 Inhibitor / Unkown
HY-19472A RWJ-58643 hydrochloride / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-RS06770 IL5 Human Pre-designed siRNA Set A / Unkown
HY-RS06771 Il5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06772 Il5 Rat Pre-designed siRNA Set A / Unkown
HY-RS06773 IL5RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169864 KRO-105714 Antagonist / Unkown
HY-174601 Human IL5RA mRNA / Unkown
HY-174602 Human IL5 mRNA / Unkown
HY-N6013R Aloin (mixture of A&B) (Standard) / Unkown
HY-RS19696 Il5ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26191 Il5ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990774 Verekitug Inhibitor 97.00% Unkown
HY-P9923A Benralizumab (anti-IL5RA ) Inducer 99.60% Unkown
HY-P9945A Mepolizumab (anti-IL5) 97.50% Unkown
HY-P990213 Anti-Mouse/Human IL-5 Antibody (TRFK5) Inhibitor 97.80% Unkown
HY-P990094 Trabikibart 99.17% Unkown
HY-P990058 Varokibart Inhibitor 95.69% Unkown
HY-P991144 Lasrekibart Ligand 97.056% Unkown
HY-P991712 Revbekitug Inhibitor 96.18% Unkown
HY-P992132 Solaprubart Inhibitor 99.59% Unkown
HY-P990452 Anti-IL-5 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il5 NCBI NCBI:3567