Scd - stearoyl-CoA desaturase Gene

Also Known as Scd1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246074

About Scd

Primary_assembly 1: 243,269,747-243,282,562 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 29 orthologues, 3 paralogues and is associated with 16 phenotypes. Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues.

Summary

Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid and unsaturated fatty acid biosynthetic process. Located in intracellular membrane-bounded organelle. Is integral component of membrane. Used to study carcinoma. Biomarker of hyperinsulinism. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]

Scd Products (1)

mRNA Protein Name
NM_139192.2 NP_631931.2 acyl-CoA desaturase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iron ion binding IDA
IDA: Inferred from direct assay
2892838 RGD
enables oxidoreductase activity IMP
IMP: Inferred from mutant phenotype
7947684 RGD
enables stearoyl-CoA 9-desaturase activity IDA
IDA: Inferred from direct assay
2892838 RGD
enables stearoyl-CoA 9-desaturase activity IMP
IMP: Inferred from mutant phenotype
7947684 RGD
Biological Process GO Annotation Evidence References Source
involved in lipid biosynthetic process IEP
IEP: Inferred from expression pattern
12896875 RGD
involved in response to fatty acid IDA
IDA: Inferred from direct assay
1982442 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
involved in unsaturated fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
2892838 RGD
involved in unsaturated fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
7947684 RGD
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
2892838 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scd Protein Structure

Delta9-FADS-like

Delta9-FADS-like: cd03505 (98 - 335)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

acyl-CoA desaturase 1

  • delta(9)-desaturase 1

  • fatty acid desaturase 1

  • stearoyl-CoA desaturase 1

  • stearoyl-Coenzyme A desaturase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18681 Voxelotor Inhibitor 99.99% Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19796 Icomidocholic acid 99.98% Phase 3
HY-148788 Osivelotor Inhibitor 98.10% Phase 3
HY-13070 MK-8245 Inhibitor 99.04% Phase 2
HY-175742 BMS-986470 Degrader 99.78% Phase 2
HY-132847 Vibozilimod Agonist 99.52% Phase 2
HY-19762 GSK1940029 Inhibitor 99.82% Phase 1
HY-139293 PF-07059013 / Phase 1

Pre-clinical Phase

Bioactive Molecules (52)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50709 A939572 Inhibitor 99.98% Unkown
HY-15823 CAY10566 Inhibitor 99.93% Unkown
HY-15700 PluriSIn 1 99.72% Unkown
HY-155033 SSI-4 99.99% Unkown
HY-12756 E6446 98.78% Unkown
HY-12756A E6446 dihydrochloride 99.29% Unkown
HY-15822 MF-438 Inhibitor 99.92% Unkown
HY-124876 SynuClean-D Inhibitor 99.89% Unkown
HY-127143 Sterculic acid Inhibitor ≥99.0% Unkown
HY-169761B (R,R)-dWIZ-1 TFA Control 98.58% Unkown
HY-141525 SCD1 inhibitor-4 Inhibitor 98.73% Unkown
HY-112812 SCD1 inhibitor-1 Inhibitor 99.91% Unkown
HY-124346 T-3364366 99.80% Unkown
HY-N6807 Elemicin Inhibitor 98.02% Unkown
HY-113638 CVT-11127 99.94% Unkown
HY-124751 YTX-465 Inhibitor 99.06% Unkown
HY-139077 SCD1 inhibitor-3 Inhibitor 98.24% Unkown
HY-11034 CVT-12012 Inhibitor 99.58% Unkown
HY-E70265 18:0 Coenzyme A triammonium 99.9% Unkown
HY-N3388 Licoisoflavone B Inhibitor 99.46% Unkown
HY-155403 SCD1/5-IN-1 Inhibitor 99.07% Unkown
HY-178486 SH6 99.43% Unkown
HY-100249 XEN723 Inhibitor 99.30% Unkown
HY-W011197 Cbz-L-Trp-OH Inhibitor 99.97% Unkown
HY-102045 T-3764518 Inhibitor 99.86% Unkown
HY-124084A SW203668 TFA Inhibitor 99.79% Unkown
HY-RS12496 Scd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13077 MK-8245 Trifluoroacetate Inhibitor 98.45% Unkown
HY-163820 WIZ degrader 4 Degrader 99.37% Unkown
HY-N7521 Procyanidin C2 / Unkown
HY-RS12494 SCD Human Pre-designed siRNA Set A / Unkown
HY-111315 XEN103 Inhibitor / Unkown
HY-114184 MK-8245 analog Inhibitor / Unkown
HY-114606 SW208108 Inhibitor / Unkown
HY-118117 Rovatirelin / Unkown
HY-124084 SW203668 Inhibitor / Unkown
HY-125475 Rivipansel Antagonist / Unkown
HY-150125 SCD1-IN-1 Inhibitor / Unkown
HY-152775A RK-0133114 Inhibitor / Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-170570 PFM046 / Unkown
HY-176274 FASN/SCD-IN-1 / Unkown
HY-182046 HD202A / Unkown
HY-34603 1-Methyl-1H-pyrazole-3-carboxylic acid 99.53% Unkown
HY-RS12495 Scd Rat Pre-designed siRNA Set A / Unkown
HY-RS12497 SCD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W175543 Methoxyurea Substrate / Unkown
HY-155209 SCD1 inhibitor-5 Inhibitor / Unkown
HY-163824 WIZ degrader 7 Degrader / Unkown
HY-18681S Voxelotor-d6 Inhibitor / Unkown
HY-N10612 Petasin / Unkown
HY-W009121 Cbz-D-Trp-OH Inhibitor 98.26% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991465 Anti-CD27 Antibody (M2177) Inhibitor / Unkown
HY-P991466 Anti-CD27 Antibody (M2191) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scd NCBI NCBI:6319