CD80 - Cd80 Cd80 molecule Gene
Also Known as B7-1
Species: Rattus norvegicus
Gene Type: protein coding
Gene ID: 25408
Summary
Predicted to enable coreceptor activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Apr 2022]
CD80 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012926.2 | NP_037058.2 | T-lymphocyte activation antigen CD80 |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of T cell proliferation |
IMP
IMP: Inferred from mutant phenotype
|
9237108 | RGD |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
15474526 | RGD |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-lymphocyte activation antigen CD80 |
|
|
Recombinant CD80 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7634 | B7-1/CD80 Protein, Rat (HEK293, His) | O35187 (V30-Q248) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74398 | B7-1/CD80 Protein, Rat (HEK293, Fc) | AAB60503.1 (I39-Q248) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Inhibitory Antibodies
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P9919 | Durvalumab | Inhibitor | 99.60% | Unkown |
Clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-148511 | Vidutolimod | 93.85% | Phase 3 |
Inhibitory Antibodies
(9)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-P99293 | Galiximab | 99.23% | Phase 3 | |
| HY-P9996 | Reozalimab | Inhibitor | 99.90% | Phase 2 |
| HY-P99809 | Quavonlimab | Inhibitor | ≥99.0% | Phase 2 |
| HY-P990992 | Efzilonkofusp alfa | / | Phase 2 | |
| HY-P991566 | KD6001 | Inhibitor | / | Phase 2 |
| HY-P99844 | Davoceticept | 99.9% | Phase 1 | |
| HY-P99709 | Lodapolimab | Inhibitor | 99.71% | Phase 1 |
| HY-P991952 | ADU-1604 | Inhibitor | / | Phase 1 |
| HY-P991961 | REGN4659 | Inhibitor | / | Phase 1 |
Pre-clinical Phase
Bioactive Molecules
(18)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-150749A | ODN D-SL03 sodium | 98.57% | Unkown | |
| HY-W722277A | LCC-12 formate | Inhibitor | 99.90% | Unkown |
| HY-100891 | CD80-IN-3 | 98.02% | Unkown | |
| HY-103048A | PD-1/PD-L1-IN 3 TFA | Inhibitor | 99.34% | Unkown |
| HY-150749 | ODN D-SL03 | Inducer | 99.82% | Unkown |
| HY-N10116A | Calamenene | / | Unkown | |
| HY-103048 | PD-1/PD-L1-IN 3 | Inhibitor | / | Unkown |
| HY-160227 | ORN 06 | Activator | / | Unkown |
| HY-161833 | HSP90-IN-31 | Inhibitor | / | Unkown |
| HY-169819 | Calcium influx inducer compound 634 | / | Unkown | |
| HY-171883 | BI-5756 | / | Unkown | |
| HY-176265 | DDS5 | Inhibitor | / | Unkown |
| HY-178945 | KOR agonist 7 | / | Unkown | |
| HY-RS02269 | CD80 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-168384 | M04 | / | Unkown | |
| HY-184441 | CD28-IN-4 | Inhibitor | / | Unkown |
| HY-RS16921 | Cd80 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS23364 | Cd80 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Inhibitory Antibodies
(12)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P9919A | Durvalumab (anti-PD-L1) | Inhibitor | 99.0% | Unkown |
| HY-P991907 | Anti-CD80 Antibody (TKMF5) | 96.92% | Unkown | |
| HY-P990127 | Anti-Mouse CD80/B7-1 Antibody (RM80) | Inhibitor | 95% | Unkown |
| HY-P990128 | Anti-Rat CD80/B7-1 Antibody (3H5) | Inhibitor | / | Unkown |
| HY-P990986 | Efdelikofusp alfa | / | Unkown | |
| HY-P991826 | Anti-Mouse CD80 Antibody (16-10A1) | Inhibitor | / | Unkown |
| HY-P991831 | Anti-Mouse CD80/B7-1 Antibody (1G10) | Inhibitor | / | Unkown |
| HY-P991918 | KHK2840 | Agonist | / | Unkown |
| HY-P992062 | Anti-Mouse CD80 Antibody (TKMG48) | Agonist | / | Unkown |
| HY-P992408 | MEDI-5083 | / | Unkown | |
| HY-P992511 | CS2009 | Inhibitor | / | Unkown |
| HY-P991958 | GIGA-564 | Inhibitor | / | Unkown |
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