2. Gene
  3. Prmt5 - protein arginine N-methyltransferase 5 Gene

Prmt5 - protein arginine N-methyltransferase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jbp1; Skb1

Gene ID: 27374 | Gene type: protein coding

About Prmt5

Chromosome 14: 54,744,644-54,754,982 reverse strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 200 orthologues and is associated with 3 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues.

Summary

This gene encodes an Enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Prmt5 Products(3)

mRNA Protein Name
NM_001313907.1 NP_001300836.1 protein arginine N-methyltransferase 5 isoform 3
NM_013768.3 NP_038796.2 protein arginine N-methyltransferase 5 isoform 1
NM_001313906.1 NP_001300835.1 protein arginine N-methyltransferase 5 isoform 2

Prmt5 Protein Structure

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 289)

PRMT5

PRMT5: pfam05185 (294 - 463)

PRMT5_C

PRMT5_C: pfam17286 (467 - 634)

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  • 637 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 5

Jak-binding protein 1

SKB1 homolog

histone-arginine N-methyltransferase PRMT5

shk1 kinase-binding protein 1 homolog

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-101563 GSK3326595 Inhibitor 99.97% Phase 2
HY-139611 MRTX-1719 Inhibitor 99.40% Phase 2
HY-148419 TNG908 Inhibitor 98.89% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.69% Phase 1
Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100235 GSK591 Inhibitor 99.87% Unkown
HY-107777 LLY-283 Inhibitor 99.22% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-124131 DS-437 Inhibitor 98.00% Unkown
HY-132309 BRD0639 Inhibitor 99.17% Unkown
HY-148674 PRMT5-IN-25 Inhibitor 99.94% Unkown
HY-100025A HLCL-61 hydrochloride Inhibitor 99.95% Unkown
HY-139611C MRTX-1719 hydrochloride Inhibitor 99.22% Unkown
HY-Q36691 PRMT5-IN-30 Inhibitor ≥95% Unkown
HY-128579 DW14800 Inhibitor 99.63% Unkown
HY-126256 PRMT5-IN-1 Inhibitor / Unkown
HY-134883 PRMT5-IN-4 Inhibitor ≥99.0% Unkown
HY-141876 PRMT5-IN-14 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-150081 PRMT5-IN-21 Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-153421 PRMT5-IN-28 Inhibitor / Unkown
HY-139611B (S)-MRTX-1719 Inhibitor 97.07% Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown
HY-P3822 PRMT5-IN-23 Inhibitor / Unkown
HY-132937 PRMT5-IN-9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt5 NCBI NCBI:10419