Prmt5 - protein arginine N-methyltransferase 5 Gene

Also Known as Jbp1; Skb1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27374

About Prmt5

Chromosome 14: 54,744,644-54,754,982 reverse strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 200 orthologues and is associated with 3 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues.

Summary

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Prmt5 Products (3)

mRNA Protein Name
NM_001313907.1 NP_001300836.1 protein arginine N-methyltransferase 5 isoform 3
NM_013768.3 NP_038796.2 protein arginine N-methyltransferase 5 isoform 1
NM_001313906.1 NP_001300835.1 protein arginine N-methyltransferase 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables E-box binding IDA
IDA: Inferred from direct assay
23133559 MGI
enables chromatin binding IMP
IMP: Inferred from mutant phenotype
18347060 MGI
enables histone H2AR3 methyltransferase activity IDA
IDA: Inferred from direct assay
16699504 MGI
enables histone H4R3 methyltransferase activity IDA
IDA: Inferred from direct assay
16699504 MGI
enables histone H4R3 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
23133559 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16699504 MGI
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
23133559 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23133559 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
16699504 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18347060 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16699504 MGI
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
23048031 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
16787967 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16699504 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt5 Protein Structure

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 289)

PRMT5

PRMT5: pfam05185 (294 - 463)

PRMT5_C

PRMT5_C: pfam17286 (467 - 634)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 637 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 5

  • Jak-binding protein 1

  • SKB1 homolog

  • histone-arginine N-methyltransferase PRMT5

  • shk1 kinase-binding protein 1 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-139611 Navlimetostat Inhibitor 99.28% Phase 3
HY-101563 GSK3326595 Inhibitor 99.83% Phase 2
HY-148419 Ralometostat Inhibitor 99.90% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.84% Phase 1
HY-141876 PRT543 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12727 EPZ015666 Inhibitor 99.86% Unkown
HY-100235 GSK591 Inhibitor 99.91% Unkown
HY-107777 LLY-283 Inhibitor 98.93% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-100025A HLCL-61 hydrochloride Inhibitor 99.87% Unkown
HY-132309 BRD0639 Inhibitor 98.04% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-139611C Navlimetostat hydrochloride Inhibitor 99.61% Unkown
HY-148674 AM-9747 Inhibitor 99.76% Unkown
HY-109963 PR5-LL-CM01 Inhibitor 98.37% Unkown
HY-Q36691 PRMT5-IN-30 Inhibitor 99.35% Unkown
HY-139611B (S)-Navlimetostat Inhibitor 98.15% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-120137 CMP-5 Inhibitor 99.61% Unkown
HY-158143 AZD3470 Inhibitor 99.74% Unkown
HY-128579 DW14800 Inhibitor 99.12% Unkown
HY-126256A PRMT5-IN-1 hydrochloride Inhibitor 99.51% Unkown
HY-W072962 WX2-43 Inhibitor 99.49% Unkown
HY-111213 PRMT5-IN-20 Inhibitor 99.20% Unkown
HY-126256 PRMT5-IN-1 Inhibitor / Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-182820 YZ-836P / Unkown
HY-134883 PRMT5-IN-4 Inhibitor 99.0% Unkown
HY-182892 MC4491 Inhibitor / Unkown
HY-169708 PRMT5-IN-49 Inhibitor / Unkown
HY-173092 PRMT5 ligand 1 Ligand / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-176534 PRMT5-IN-52 Inhibitor / Unkown
HY-163593 PRMT5-IN-44 Inhibitor / Unkown
HY-111213A PRMT5-IN-20 hydrochloride Ligand / Unkown
HY-178028 PRMT5-IN-53 Inhibitor / Unkown
HY-150081 PRMT5-IN-21 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-168842 PRMT5-IN-47 Inhibitor / Unkown
HY-163587 PRMT5-IN-39-d3 Inhibitor / Unkown
HY-163799 PRMT5-MTA-IN-1 Inhibitor / Unkown
HY-P3822 PRMT5-IN-23 Inhibitor / Unkown
HY-180356 PRMT5-IN-54 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-132937 PRMT5-IN-9 Inhibitor / Unkown
HY-153421 PRMT5-IN-28 Inhibitor / Unkown
HY-176702 PRMT5-MTA-IN-5 Inhibitor / Unkown
HY-176701 PRMT5-MTA-IN-4 Inhibitor / Unkown
HY-163592 PRMT5-IN-43 Inhibitor / Unkown
HY-181522 PRMT5 ligand 3 Ligand / Unkown
HY-183951 TNG456 Inhibitor / Unkown
HY-184434 PRMT5-IN-57 Inhibitor / Unkown
HY-168263 PRMT5-IN-45 Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-163591 PRMT5-IN-36-d3 Inhibitor / Unkown
HY-181521 RAPRMT5 Degrader / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt5 NCBI NCBI:10419