Cdc42 - cell division cycle 42 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64465

Summary

Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament branching; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42 Products (1)

mRNA Protein Name
NM_171994.5 NP_741991.3 cell division control protein 42 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTP binding IDA
IDA: Inferred from direct assay
17161586 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
17161586 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15537656 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
20525016 RGD
involved in actin filament branching IMP
IMP: Inferred from mutant phenotype
17855387 RGD
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
21763307 RGD
involved in establishment of Golgi localization IMP
IMP: Inferred from mutant phenotype
20525016 RGD
involved in organelle transport along microtubule IMP
IMP: Inferred from mutant phenotype
20525016 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
9487126 RGD
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
17161586 RGD
involved in positive regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
18562481 RGD
involved in positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
21844200 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17161586 RGD
involved in positive regulation of synapse structural plasticity IMP
IMP: Inferred from mutant phenotype
21423166 RGD
involved in regulation of modification of postsynaptic structure IDA
IDA: Inferred from direct assay
21423166 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
21423166 RGD
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
18562481 RGD
involved in submandibular salivary gland formation IEP
IEP: Inferred from expression pattern
18784978 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
15147909 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
21423166 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
21423166 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15537656 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15537656 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cell division control protein 42 homolog

  • cell division cycle 42 (GTP binding protein)

  • cell division cycle 42 homolog

Cdc42 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Cdc42 Q8CFN2 BAIAP2 Homo sapiens Q9UQB8
Y2H
18448434
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-I0400 N-Acetylneuraminic acid 99.95% Phase 1
HY-112842 MBQ-167 Inhibitor 99.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (40)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-12874 CASIN 99.89% Unkown
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-111424 BDP9066 Inhibitor 98.18% Unkown
HY-13963 ZCL278 Inhibitor 98.49% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-N2438 Methylophiopogonanone B 99.84% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-136383 AZA1 98.17% Unkown
HY-136379 CID44216842 Inhibitor 99.84% Unkown
HY-B0580B (R)-Ketorolac Inhibitor 99.35% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-15031 l-Naproxen Inhibitor 99.63% Unkown
HY-149464 ARN22089 Inhibitor 98.18% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-111424A (R)-BDP9066 Inhibitor 95.75% Unkown
HY-121667 Scaff10-8 Inhibitor 99.11% Unkown
HY-RS02300 CDC42 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116269 AZA197 98.71% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-170327 ZCL279 Inhibitor 99.20% Unkown
HY-RS23116 Cdc42 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111423 BDP8900 Inhibitor / Unkown
HY-13963S ZCL278-13C / Unkown
HY-149921 Antiangiogenic agent 3 Inhibitor / Unkown
HY-161736 ARN25499 Inhibitor / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-183246 Rac/Cdc42-IN-1 Inhibitor / Unkown
HY-RS02301 CDC42BPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02302 CDC42BPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02303 CDC42EP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02304 CDC42EP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02305 CDC42EP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167828 ARN25062 Inhibitor / Unkown
HY-N15267 Ovalitenone Inhibitor / Unkown
HY-N16021 4A-MPLA ammonium / Unkown
HY-RS16681 Cdc42 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc42 NCBI NCBI:998