Cdk12 - cyclin-dependent kinase 12 Gene

Also Known as Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69131

About Cdk12

Chromosome 11: 98,093,885-98,169,330 forward strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 206 orthologues, 25 paralogues and is associated with 31 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues.

Summary

Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Cdk12 Products (3)

mRNA Protein Name
NM_001109626.1 NP_001103096.1 cyclin-dependent kinase 12 isoform 1
NM_001109628.1 NP_001103098.1 cyclin-dependent kinase 12 isoform 2
NM_026952.2 NP_081228.2 cyclin-dependent kinase 12 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IDA
IDA: Inferred from direct assay
22547058 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22547058 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk12 Protein Structure

STKc_CDK12

STKc_CDK12: cd07864 (714 - 1015)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1484 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 12

  • CDC2-related kinase 7

  • CDC2-related kinase, arginine/serine-rich

  • CDC2-related protein kinase 7

  • cell division cycle 2-related protein kinase 7

  • cell division protein kinase 12

  • protein kinase for splicing component

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138293 SY-5609 Inhibitor 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (48)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-139039 BSJ-4-116 Inhibitor 99.87% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% Unkown
HY-168555 YJ1206 Degrader 97.26% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-153244 MFH290 Inhibitor 98.29% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 99.12% Unkown
HY-112261 CDK12-IN-3 Inhibitor 99.86% Unkown
HY-163944 LL-K12-18 Inhibitor 98.42% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-168162 ZLC491 Degrader 98.51% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.88% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-171787A PPA-037 TFA Inhibitor 99.42% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader 98.01% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-144691 PP-C8 Inhibitor 99.99% Unkown
HY-172970 HQY1428 Inhibitor 99.65% Unkown
HY-168556 YJ9069 Degrader / Unkown
HY-173059 CDK12/13-IN-3 Inhibitor 99.14% Unkown
HY-171786 CDK12-IN-8 Inhibitor 99.52% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-171787 PPA-037 Inhibitor / Unkown
HY-181035 DN1679 Degrader / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-181405 SR-5037 Inhibitor 99.58% Unkown
HY-176279 Hsp90-IN-42 Inhibitor / Unkown
HY-168658 CDK12/13 ligand 2 Degrader / Unkown
HY-48507 CDK12/13 ligand 4 Ligand / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-173273 YJZ5118 Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-114567 GW780056X Inhibitor / Unkown
HY-150948 CDK12 ligand-2 Ligand / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-168163 CDK12/13 ligand 1 Degrader / Unkown
HY-173042 CDK12/13-IN-2 Inhibitor / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-181036 CDK12/13 ligand 3 Ligand / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-172224 PARP1/CDK12-IN-1 Inhibitor / Unkown
HY-176790 CDK12-Cyclin K ligand-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk12 NCBI NCBI:51755