TMPRSS2 - transmembrane serine protease 2 Gene

Also Known as PRSS10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7113

About TMPRSS2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,464,305-41,508,158 (from NCBI)

This gene has 20 transcripts (splice variants), 229 orthologues, 17 paralogues and is associated with 72 phenotypes. Biased expression in prostate (RPKM 167.2), colon (RPKM 59.9) and 10 other tissues.

Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic Hormones in prostate Cancer cells and down-regulated in androgen-independent prostate Cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza Virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

TMPRSS2 Products (3)

mRNA	Protein	Name
NM_001135099.1	NP_001128571.1	transmembrane protease serine 2 isoform 1
NM_001382720.1	NP_001369649.1	transmembrane protease serine 2 isoform 3
NM_005656.4	NP_005647.3	transmembrane protease serine 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21068237	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	25122198	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	21068237	GOA
involved in protein autoprocessing	IMP IMP: Inferred from mutant phenotype	21068237	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	21068237	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21068237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS2 Protein Structure

SRCR_2

Trypsin

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
transmembrane protease serine 2	epitheliasin

TMPRSS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMPRSS2	O15393	ACE2	Homo sapiens	Q9BYF1	Anti Tag CoIP	21068237
Intra	TMPRSS2	O15393	ACE2	Homo sapiens	Q9BYF1	Confocal	21068237
Intra	TMPRSS2	O15393	SERPINA1	Homo sapiens	P01009	Cleavage	33741941
Intra	TMPRSS2	O15393	SERPINA1	Homo sapiens	P01009	SPR	33741941

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMPRSS2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72043	TMPRSS2 Protein, Human (P.pastoris, His)	O15393-1 (W106-G492)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72044	TMPRSS2 Protein, Human (R255Q, HEK293, His)	O15393-1 (W106-G492, R255Q)	≥ 95%, as determined by reducing SDS-PAGE.

TMPRSS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82611	Transmembrane Protease Serine 2 Antibody (YA2356)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Coronavirus Infectious Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Long Covid	Post-Acute Sequelae Of Sars-Cov-2 Infection Chronic Covid-19 Pasc Post-Covid Syndrome
Critical Covid-19
Acute Hemorrhagic Conjunctivitis	Viral Conjunctivitis Conjunctivitis, Acute Hemorrhagic Apollo Disease Epidemic Hemorrhagic Conjunctivitis Viral Conjunctiva Disorder Viral Conjunctivitis Nos
Severe Covid-19
Viral Pneumonia	Pneumonia, Viral Acute Viral Pneumonia Bronchopneumonia Due To Viruses Other Than Influenza Viruses Interstitial Viral Pneumonia Viral Bronchopneumonia Viral Double Pneumonia Viral Lobar Pneumonia Viral Purulent Pneumonia Virus Interstitial Pneumonia Virus Lobar Pneumonia
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Non-Severe Covid-19
Orchitis	Inflammation Of Testis Orchititis Mumps Orchitis
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Prostatic Acinar Adenocarcinoma	Acinar Prostate Adenocarcinoma
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Peptic Esophagitis	Reflux Esophagitis Peptic Reflux Disease Reflux Oesophagitis Esophagitis, Peptic Gastro-Esophageal Reflux Disease With Esophagitis
Subacute Thyroiditis	Giant-Cell Thyroiditis Granulomatous Thyroiditis Subacute Granulomatous Thyroiditis De Quervain'S Thyroiditis Thyroiditis Subacute Thyroiditis, Subacute Pseudogranulomatous Thyroiditis De Quervain Thyroiditis Nonsuppurative Subacute Thyroiditis Pseudotuberculous Thyroiditis Nonsuppurative Thyroiditis Nos
Common Cold	Acute Coryza Acute Nasopharyngitis Acute Rhinitis Acute Viral Rhinopharyngitis Nasopharyngitis - Acute Nasopharyngitis, Acute Rhino-Sinusitis Rhinosinusitis Common Colds Acute Infective Rhinitis Cold Coryza Head Cold Infective Nasopharyngitis Rhinopharyngitis Acute Nasal Catarrh Infective Rhinitis Acute Nasopharyngeal Catarrh Infective Nasopharyngitis Nos Nasopharyngitis Nos Epipharyngitis Mucositis Nos Inflammatory Disease Of Mucous Membrane Mucosal Inflammation
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Herpangina	Vesicular Pharyngitis
Acute Dacryoadenitis
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Extrinsic Cardiomyopathy
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13512	Camostat mesylate	Inhibitor	99.94%	Unkown
HY-B0372A	Bromhexine hydrochloride		99.93%	Unkown
HY-B1624A	Debrisoquin hemisulfate		99.94%	Unkown
HY-B1624	Debrisoquin	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-130402B	Propamidine		96.15%	Phase 3

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135794	11-Ketodihydrotestosterone	Agonist	99.87%	Unkown
HY-134432B	Boc-Gln-Ala-Arg-AMC acetate		99.99%	Unkown
HY-15290	AIM-100	Inhibitor	99.95%	Unkown
HY-114402	ARD-69	Degrader	99.61%	Unkown
HY-148072	MM3122	Inhibitor	99.20%	Unkown
HY-W195509	Debrisoquin hydroiodide	Inhibitor	99.84%	Unkown
HY-108447	BC-11 hydrobromide	Inhibitor	99.22%	Unkown
HY-W749874	Qingdainone	Inhibitor	96.88%	Unkown
HY-170820	XYD049	Inhibitor	99.46%	Unkown
HY-157154	MAT-POS-e194df51-1	Inhibitor	98.45%	Unkown
HY-168201	MJP6412		95.90%	Unkown
HY-B0372AS	Bromhexine-d3 hydrochloride		99.0%	Unkown
HY-105747A	Guanoxyfen nitrate		/	Unkown
HY-117744	NMS-P645	Inhibitor	/	Unkown
HY-134432A	Boc-Gln-Ala-Arg-AMC hydrochloride		/	Unkown
HY-156441	SARS-CoV-2-IN-65	Inhibitor	/	Unkown
HY-157021	SARS-CoV-2-IN-66	Inhibitor	/	Unkown
HY-158073	ML2006a4	Inhibitor	/	Unkown
HY-161370	VD4162	Inhibitor	/	Unkown
HY-161902	MI-1904	Inhibitor	/	Unkown
HY-174350	CK2-IN-15	Inhibitor	/	Unkown
HY-175344	TMP1	Inhibitor	/	Unkown
HY-179123	ZC9		/	Unkown
HY-184896	XYD113	Inhibitor	/	Unkown
HY-B1624C	Debrisoquin hydrobromide	Inhibitor	/	Unkown
HY-RS14769	TMPRSS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157022	SARS-CoV-2-IN-67	Inhibitor	/	Unkown
HY-162604	SARS-CoV-2-IN-90	Inhibitor	/	Unkown
HY-162719	RH12	Inhibitor	/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown
HY-163067	SARS-CoV-2-IN-71	Inhibitor	/	Unkown
HY-173148	TKB272	Inhibitor	/	Unkown
HY-173421	(H)S(OMe)-DFR-kbt	Inhibitor	/	Unkown
HY-173459	N-0920	Inhibitor	/	Unkown
HY-179708	Cbz-QFR-kbt	Inhibitor	/	Unkown
HY-RS16739	Tmprss2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23176	Tmprss2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990524	Anti-TMPRSS2 Antibody	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMPRSS2	VGNC	VGNC:78575
Canis familiaris	TMPRSS2	VGNC	VGNC:53045
Bos taurus	TMPRSS2	VGNC	VGNC:36140
Felis catus	TMPRSS2	VGNC	VGNC:66385
Mus musculus	TMPRSS2	MGD	MGI:1354381
Others	TMPRSS2	NCBI