Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

Rattus norvegicus

Also known as ROCK-I; P160Rock

Gene ID: 81762 | Gene type: protein coding

About Rock1

Primary_assembly 18: 1,115,905-1,235,571 reverse strand.mRatBN7.2:CM026991.1

This gene has 2 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 7 phenotypes. Biased expression in Thymus (RPKM 255.8), Lung (RPKM 241.4) and 9 other tissues.

Summary

Enables small GTPase binding activity. Involved in Cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Predicted to be located in lamellipodium; plasma membrane; and ruffle. Predicted to be part of amyloid-beta complex. Predicted to be active in cytoplasmic stress granule and Cytoskeleton. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rock1 Products(1)

mRNA	Protein	Name
NM_001389239.1	NP_001376168.1	rho-associated protein kinase 1

Rock1 Protein Structure

STKc_ROCK1

SMC_prok_B

HR1_ROCK1

ROCK_SBD

PH_ROCK

C1_ROCK1

0
300
600
900
1200
1354 a.a.

Protein Preferred Names

Protein Names

rho-associated protein kinase 1

Rho-associated coiled-coil forming kinase 1	Rho-associated kinase beta
liver regeneration-related protein LRRG199	p150 RhoA-binding kinase ROK beta
p160 ROCK-1	rho-associated, coiled-coil-containing protein kinase 1
rho-associated, coiled-coil-containing protein kinase I

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10341	Fasudil Hydrochloride	Inhibitor	99.96%	Yes
HY-15307	Belumosudil	Inhibitor	99.77%	Yes
HY-15685	Ripasudil	Inhibitor	99.92%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.42%	Unkown
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.88%	Yes
HY-10341A	Fasudil	Inhibitor	/	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	/	Unkown
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	98.31%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.79%	Phase 3
HY-15687A	SAR407899	Inhibitor	99.86%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	98.66%	Phase 2
HY-16071	AT13148	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.97%	Unkown
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-15392	Chroman 1	Inhibitor	99.48%	Unkown
HY-15556	GSK269962A	Inhibitor	99.83%	Unkown
HY-11000	GSK429286A	Inhibitor	98.15%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.87%	Unkown
HY-15755	RKI-1447	Inhibitor	98.29%	Unkown
HY-18990	GSK180736A	Inhibitor	98.01%	Unkown
HY-13300	SR-3677	Inhibitor	99.90%	Unkown
HY-12437	BDP5290	Inhibitor	98.80%	Unkown
HY-16758	Verosudil	Inhibitor	99.18%	Unkown
HY-14362	GSK-25	Inhibitor	99.68%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-126275	HSD1590	Inhibitor	99.54%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	98.04%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	Unkown
HY-107209	RKI-1313	Inhibitor	≥98.0%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-132302	Hu7691	Inhibitor	/	Unkown
HY-14227	LIMK-IN-1	Inhibitor	/	Unkown
HY-122011	PF-4950834	Inhibitor	/	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	/	Unkown
HY-149266	THK01	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rock1	NCBI	NCBI:6093

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