Cat. No.: HY-17039

Alcaftadine

(Synonyms: R89674)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects.

For research use only. We do not sell to patients.

Purity: 98.37%
CAS No.: 147084-10-4
Formula: C₁₉H₂₁N₃O
Molecular Weight:307.39

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Alcaftadine Chemical Structure

CAS No.: 147084-10-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

H₁ Receptor

H₂ Receptor

All Histamine Receptor Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 147084-10-4
Appearance Solid
Molecular Weight 307.39
Formula C₁₉H₂₁N₃O
Color Light yellow to yellow
SMILES

O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4
Synonyms

R89674
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Int J Biol Macromol

Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]

2026 Mar:352:151224. PMID: 41791543

Solvent & Solubility

In Vitro:

DMSO : ≥ 40 mg/mL (130.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2532 mL

16.2660 mL

32.5320 mL

5 mM

0.6506 mL

3.2532 mL

6.5064 mL

10 mM

0.3253 mL

1.6266 mL

3.2532 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90. [Content Brief]

[2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2532 mL	16.2660 mL	32.5320 mL	81.3299 mL
	5 mM	0.6506 mL	3.2532 mL	6.5064 mL	16.2660 mL
	10 mM	0.3253 mL	1.6266 mL	3.2532 mL	8.1330 mL
	15 mM	0.2169 mL	1.0844 mL	2.1688 mL	5.4220 mL
	20 mM	0.1627 mL	0.8133 mL	1.6266 mL	4.0665 mL
	25 mM	0.1301 mL	0.6506 mL	1.3013 mL	3.2532 mL
	30 mM	0.1084 mL	0.5422 mL	1.0844 mL	2.7110 mL
	40 mM	0.0813 mL	0.4066 mL	0.8133 mL	2.0332 mL
	50 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6266 mL
	60 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL
	80 mM	0.0407 mL	0.2033 mL	0.4066 mL	1.0166 mL
	100 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL

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Alcaftadine

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Publications Citing Use of MedChemExpress (MCE) Alcaftadine

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Alcaftadine Related Classifications

HY-17039 Related Classifications