AD4
Based on 1 publication(s) in Google Scholar
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2918262-09-4
- Formula: C55H78N4O15
- Molecular Weight:1035.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AD4
MoreAll PROTACs Isoforms
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Biological Activity
IC50: 0.6 nM (PCLAF/KIAA0101)[1]
Chemical Information
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CAS No. 2918262-09-4
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Appearance Solid
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Molecular Weight 1035.23
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Formula C55H78N4O15
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Color Light yellow to yellow
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SMILES
C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(C(CCCCCCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CCO[C@H]8O[C@@]9([H])[C@]%10%11[C@](CC[C@H]([C@]%10([H])CC[C@](O9)(OO%11)C)C)([H])[C@H]8C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Glia
Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia. [Abstract]2024 Feb;72(2):433-451. PMID: 37870193
Solvent & Solubility
DMSO : 100 mg/mL (96.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9660 mL | 4.8298 mL | 9.6597 mL | 24.1492 mL |
| 5 mM | 0.1932 mL | 0.9660 mL | 1.9319 mL | 4.8298 mL | |
| 10 mM | 0.0966 mL | 0.4830 mL | 0.9660 mL | 2.4149 mL | |
| 15 mM | 0.0644 mL | 0.3220 mL | 0.6440 mL | 1.6099 mL | |
| 20 mM | 0.0483 mL | 0.2415 mL | 0.4830 mL | 1.2075 mL | |
| 25 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9660 mL | |
| 30 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8050 mL | |
| 40 mM | 0.0241 mL | 0.1207 mL | 0.2415 mL | 0.6037 mL | |
| 50 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4830 mL | |
| 60 mM | 0.0161 mL | 0.0805 mL | 0.1610 mL | 0.4025 mL | |
| 80 mM | 0.0121 mL | 0.0604 mL | 0.1207 mL | 0.3019 mL |
AD4 Related Classifications
HY-149428 Related Classifications
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