DETD-35
DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy.
For research use only. We do not sell to patients.
- CAS No.: 1836209-98-3
- Formula: C27H24O6
- Molecular Weight:444.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Stat-3 |
Chemical Information
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CAS No. 1836209-98-3
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Molecular Weight 444.48
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Formula C27H24O6
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SMILES
O=C(O[C@H]1[C@H](C(C(O2)=O)=C)[C@@H]2CC(C(O3)=O)=C[C@H]3C/C(C)=C/1)CC4=CC=CC5=C4C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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