RIN1 - Ras and Rab interactor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9610

About RIN1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,330,241-66,336,774 (from NCBI)

This gene has 8 transcripts (splice variants), 238 orthologues and 6 paralogues. Broad expression in skin (RPKM 7.4), stomach (RPKM 2.6) and 21 other tissues.

Summary

Predicted to enable small GTPase binding activity. Predicted to be involved in endocytosis; regulation of catalytic activity; and signal transduction. Predicted to act upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIN1 Products (3)

mRNA Protein Name
NM_001363559.2 NP_001350488.1 ras and Rab interactor 1 isoform 2
NM_001363560.2 NP_001350489.1 ras and Rab interactor 1 isoform 3
NM_004292.3 NP_004283.2 ras and Rab interactor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9144171 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12574403 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12574403 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIN1 Protein Structure

VPS9

VPS9: Vacuolar sorting protein 9 (VPS9) domain (492 - 591)

RA

RA: Ras association (RalGDS/AF-6) domain (625 - 708)

  • 0
  • 200
  • 400
  • 600
  • 783 a.a.
Protein Preferred Names Protein Names

ras and Rab interactor 1

  • ras inhibitor 1

RIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RIN1 Q13671 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
RIN1 Q13671 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 ABL2 Homo sapiens P42684
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 ABL2 Homo sapiens P42684
Anti Tag CoIP
28514442
Intra
RIN1 Q13671 ABL2 Homo sapiens P42684
Anti Tag CoIP
15886098
Intra
RIN1 Q13671 ABL2 Homo sapiens P42684
Anti Bait CoIP
15886098
Intra
RIN1 Q13671 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
RIN1 Q13671 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
RIN1 Q13671 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra
RIN1 Q13671 CRACR2B Homo sapiens Q8N4Y2-3
Validated Y2H
32296183
Intra
RIN1 Q13671 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Array
32296183
Intra
RIN1 Q13671 KRTAP15-1 Homo sapiens Q3LI76
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
Intra
RIN1 Q13671 KRTAP15-1 Homo sapiens Q3LI76
Y2H Array
32296183
Intra
RIN1 Q13671 CAPNS2 Homo sapiens Q96L46
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 CAPNS2 Homo sapiens Q96L46
Validated Y2H
32296183
Intra
RIN1 Q13671 CAPNS2 Homo sapiens Q96L46
Y2H Array
32296183
Intra
RIN1 Q13671 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
RIN1 Q13671 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra
RIN1 Q13671 CCM2 Homo sapiens Q9BSQ5
Validated Y2H
32296183
Intra
RIN1 Q13671 CCM2 Homo sapiens Q9BSQ5
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 CCM2 Homo sapiens Q9BSQ5
Y2H Array
32296183
Intra
RIN1 Q13671 TBC1D1 Homo sapiens Q86TI0
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TBC1D1 Homo sapiens Q86TI0
Validated Y2H
32296183
Intra
RIN1 Q13671 TBC1D1 Homo sapiens Q86TI0
Y2H Array
32296183
Intra
RIN1 Q13671 SNX17 Homo sapiens Q15036
Validated Y2H
32296183
Intra
RIN1 Q13671 SNX17 Homo sapiens Q15036
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 SNX17 Homo sapiens Q15036
Y2H Array
32296183
Intra
RIN1 Q13671 ANKS1B Homo sapiens Q7Z6G8-3
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 ANKS1B Homo sapiens Q7Z6G8-3
Validated Y2H
32296183
Intra
RIN1 Q13671 ANKS1B Homo sapiens Q7Z6G8-3
Y2H Array
32296183
Intra
RIN1 Q13671 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Intra
RIN1 Q13671 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
RIN1 Q13671 EGFR Homo sapiens P00533
Confocal
17403676
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Anti Tag CoIP
9144171
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Y2H
9144171
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Anti Bait CoIP
9144171
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Anti Tag CoIP
28514442
Intra
RIN1 Q13671 HRAS Homo sapiens P01112
Anti Tag CoIP
34591612
Intra
RIN1 Q13671 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
RIN1 Q13671 YWHAE Homo sapiens P62258
Y2H
11784866
Intra
RIN1 Q13671 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 YWHAE Homo sapiens P62258
Anti Tag CoIP
28514442
Intra
RIN1 Q13671 YWHAE Homo sapiens P62258
Anti Tag CoIP
31980649
Intra
RIN1 Q13671 STAM2 Homo sapiens O75886
Anti Tag CoIP
17403676
Intra
RIN1 Q13671 STAM2 Homo sapiens O75886
Confocal
17403676
Intra
RIN1 Q13671 STAM2 Homo sapiens O75886
Anti Bait CoIP
17403676
Intra
RIN1 Q13671 ABL1 Homo sapiens P00519
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 ABL1 Homo sapiens P00519
Anti Bait CoIP
15886098
Intra
RIN1 Q13671 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
RIN1 Q13671 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
RIN1 Q13671 RRAS2 Homo sapiens P62070
Y2H Pooling
19060904
Intra
RIN1 Q13671 RRAS2 Homo sapiens P62070
Y2H Array
19060904
Intra
RIN1 Q13671 RRAS2 Homo sapiens P62070
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 RRAS2 Homo sapiens P62070
Anti Tag CoIP
28514442
Intra
RIN1 Q13671 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32296183
Intra
RIN1 Q13671 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra
RIN1 Q13671 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
RIN1 Q13671 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RIN1 Q13671 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TRIP10 Homo sapiens Q15642-2
Validated Y2H
32296183
Intra
RIN1 Q13671 TRIP10 Homo sapiens Q15642-2
Y2H Array
32296183
Intra
RIN1 Q13671 TRIP10 Homo sapiens Q15642-2
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
RIN1 Q13671 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 EIF3F Homo sapiens O00303
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 EIF3F Homo sapiens O00303
Y2H Array
32296183
Intra
RIN1 Q13671 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
RIN1 Q13671 NRAS Homo sapiens P01111
Anti Tag CoIP
33961781
Intra
RIN1 Q13671 NRAS Homo sapiens P01111
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 NRAS Homo sapiens P01111
Anti Tag CoIP
28514442
Intra
RIN1 Q13671 NRAS Homo sapiens P01111
Y2H Array
32296183
Intra
RIN1 Q13671 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
RIN1 Q13671 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
RIN1 Q13671 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
RIN1 Q13671 TRIM23 Homo sapiens P36406
Validated Y2H
32296183
Intra
RIN1 Q13671 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
RIN1 Q13671 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra
RIN1 Q13671 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra
RIN1 Q13671 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Intra
RIN1 Q13671 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra
RIN1 Q13671 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
26871637
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
26871637
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Array
26871637
Intra
RIN1 Q13671 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
RIN1 Q13671 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
RIN1 Q13671 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 SEC23B Homo sapiens Q15437
Validated Y2H
32296183
Intra
RIN1 Q13671 SEC23B Homo sapiens Q15437
Y2H Array
32296183
Intra
RIN1 Q13671 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
RIN1 Q13671 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
RIN1 Q13671 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
RIN1 Q13671 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
RIN1 Q13671 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137471 RBPJ Inhibitor-1 Inhibitor 99.87% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.04% Unkown
HY-100328 CB2R-IN-1 Inhibitor / Unkown
HY-149014 OX2R-IN-1 Inhibitor / Unkown
HY-149358 NK3R-IN-1 Inhibitor / Unkown
HY-159941 tau-0N4R-IN-1 Inhibitor / Unkown
HY-162062 EGFR WT/T790M/L858R-IN-1 Inhibitor / Unkown
HY-170687 AT2R-IN-1 Inhibitor / Unkown
HY-176405 σ1R-IN-1 Inhibitor / Unkown
HY-RS11982 RIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17055 Rin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23499 Rin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RIN1 VGNC VGNC:45586
Rattus norvegicus RIN1 RGD RGD:620006
Mus musculus RIN1 MGD MGI:2385695
Bos taurus RIN1 VGNC VGNC:33975
Felis catus RIN1 VGNC VGNC:64633
Macaca mulatta RIN1 VGNC VGNC:76769
Others RIN1 NCBI