L1BC8
Based on 1 Customer Validation
L1BC8 (Compound 13a) is a drug-linker conjugate for ADC. L1BC8 is obtained by conjugating a BRD4 PROTAC degrader with a peptidomimetic protease-cleavable linker for the preparation of ADC, which can be conjugated to STEAP1 antibodies and CLL1 antibodies, respectively. L1BC8 can be used in research related to prostate cancer and acute myeloid leukemia.
(Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663)).
For research use only. We do not sell to patients.
- Purity : 99.20%
- CAS No.: 2417370-68-2
- Formula: C86H98F2N16O18S2
- Molecular Weight:1745.92
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
BRD4 |
In Vitro
The drug-linker conjugate of an antibody-drug conjugate (ADC) consists of an active cytotoxic drug and an appropriate linker. These conjugates, when linked to a monoclonal antibody, can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.
PROTAC stands for proteolysis-targeting chimeras, a type of heterobifunctional small molecule compound containing two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "three-body" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase closer together. PROTACs can improve the druggability of "undruggable" targets.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417370-68-2
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Appearance Solid
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Molecular Weight 1745.92
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Formula C86H98F2N16O18S2
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Color White to off-white
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SMILES
O=C(OCC1=CC=C(NC([C@@H](NC(C2(CCC2)C(NCCCCCN3C(C=CC3=O)=O)=O)=O)CCCNC(N)=O)=O)C=C1)NC4=CC(CCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=CC(OCCNC(C8=C(CS(=O)(C)=O)C=C(C(N(C9=NC=C(F)C=C9F)C%10)=C8)C%11=CN(C)C(C%12=C%11C%10=CN%12)=O)=O)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L1BC8 Related Classifications
HY-164995 Related Classifications
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