Cat. No.: HY-111431A

p-Cresyl sulfate potassium

(Synonyms: p-Tolyl sulfate potassium)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.

For research use only. We do not sell to patients.

Purity: 99.97%
CAS No.: 91978-69-7
Formula: C₇H₇KO₄S
Molecular Weight:226.29

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

p-Cresyl sulfate potassium Chemical Structure

CAS No.: 91978-69-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All JNK Isoforms :

All p38 MAPK Isoforms :

In Vitro

p-Cresyl sulfate potassium (0.125 mM, 24 h) induces osteoblast dysfunction by activating JNK and p38 MAPK pathways^[1].
p-Cresyl sulfate potassium (40 μg/mL, 30 min) inhibits adipogenesis and increases lipolysis of adipocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Primary osteoblastic cells
Concentration:

0.05, 0.125, 0.25, 0.5 mM
Incubation Time:

24 h
Result:

Decreased cell viability in a dose-dependent manner.

Cell Proliferation Assay^[1]

Cell Line:

Primary osteoblastic cells
Concentration:

0.05, 0.125, 0.25, 0.5 mM
Incubation Time:

24 h
Result:

Increased DNA fragmentation and decreased cell proliferation.

Western Blot Analysis^[1]

Cell Line:

Primary osteoblastic cells
Concentration:

0.125 mM
Incubation Time:

24 h
Result:

Induced rapid and sustained phosphorylation of JNK.

In Vivo

p-Cresyl sulfate potassium (10 mg/kg intraperitoneal injection twice daily for 4 weeks) promotes insulin resistance associated with CKD in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CKD mice modrl^[2]
Dosage:

10 mg/kg
Administration:

i.p.
Result:

Increased fasting plasma glucose concentration and plasma cholesterol levels.

Chemical Information

CAS No. 91978-69-7
Appearance Solid
Molecular Weight 226.29
Formula C₇H₇KO₄S
Color White to off-white
SMILES

O=S(OC1=CC=C(C)C=C1)(O[K])=O
Synonyms

p-Tolyl sulfate potassium
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All WBCell Proliferation/Viability AssayFlow Cytometry

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Journal Impact Factor

Cell Metab

Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]

2024 Jun 18:S1550-4131(24)00189-X. PMID: 38897198
Cell Death Dis

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells. [Abstract]

2023 Feb 2;14(2):78. PMID: 36732325

p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 2;14(2):78. [Abstract]

HK-2 and NRK49F cells were treated with 400 μM IS, p-Cresyl sulfate (p-CS) and CMPF under serum starvation for 24 h and harvested. GPX4 protein levels in cells treated with 400 μM uremic toxin as detected by immunoblotting. The relative protein levels are shown.

p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 2;14(2):78. [Abstract]

HK-2 and NRK49F cells were treated with 400 μM IS, p-Cresyl sulfate (p-CS) and CMPF under serum starvation for 24 h and harvested. GPX4 protein levels in cells treated with uremic toxin as detected by flow cytometry. The graph on right shows the mean value of GPX4 fluorescence.
Phytomedicine

Huangqi Jianzhong decoction improves gastric intestinal metaplasia in rats by regulating the gut‒thyroid axis. [Abstract]

2024 Oct 28:135:156174. PMID: 39488101

p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Oct 28:135:156174. [Abstract]

Indoxyl sulfate compromises mitochondrial function in Nthy-ori 3–1 cells. Survival rate of Nthy-ori 3–1 cells treated with p-Cresol sulfate.
Colloids Surf B Biointerfaces

Trimethylamine N-oxide detection by electrochemical sensor based on screen printed electrode modified with molecularly imprinted polypyrrole-molybdenum(III) sulfide nanosheets. [Abstract]

2024 Aug 13:244:114164. PMID: 39180990
Electrochim Acta

2025 Oct 26.
ACS Appl Bio Mater

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer. [Abstract]

2024 Jun 17;7(6):3841-3853. PMID: 38836520

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (552.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (441.91 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4191 mL

22.0955 mL

44.1911 mL

5 mM

0.8838 mL

4.4191 mL

8.8382 mL

10 mM

0.4419 mL

2.2096 mL

4.4191 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (220.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tanaka H, et al, Fukagawa M. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56(2):347-54. [Content Brief]

[2]. Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24(1):88-99. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	4.4191 mL	22.0955 mL	44.1911 mL	110.4777 mL
	5 mM	0.8838 mL	4.4191 mL	8.8382 mL	22.0955 mL
	10 mM	0.4419 mL	2.2096 mL	4.4191 mL	11.0478 mL
	15 mM	0.2946 mL	1.4730 mL	2.9461 mL	7.3652 mL
	20 mM	0.2210 mL	1.1048 mL	2.2096 mL	5.5239 mL
	25 mM	0.1768 mL	0.8838 mL	1.7676 mL	4.4191 mL
	30 mM	0.1473 mL	0.7365 mL	1.4730 mL	3.6826 mL
	40 mM	0.1105 mL	0.5524 mL	1.1048 mL	2.7619 mL
	50 mM	0.0884 mL	0.4419 mL	0.8838 mL	2.2096 mL
	60 mM	0.0737 mL	0.3683 mL	0.7365 mL	1.8413 mL
	80 mM	0.0552 mL	0.2762 mL	0.5524 mL	1.3810 mL
	100 mM	0.0442 mL	0.2210 mL	0.4419 mL	1.1048 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

p-Cresyl sulfate potassium

6 Cited Publications

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p-Cresyl sulfate potassium

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Publications Citing Use of MedChemExpress (MCE) p-Cresyl sulfate potassium

All Endogenous Metabolite Isoforms

All JNK Isoforms

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

p-Cresyl sulfate potassium Related Classifications

HY-111431A Related Classifications