AST5902
AST5902 is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 can be used in research related to non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2412155-74-7
- Formula: C27H29F3N8O2
- Molecular Weight:554.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
Description
IC50 & Target
|
CYP3A4 |
EGFR |
In Vitro
AST5902 exhibits anti-tumor activity comparable to that of its parent compound Furmonertinib (HY-112870), a potent EGFR inhibitor.[1]
AST5902 is generated via CYP3A4-mediated N-demethylation of Furmonertinib in human liver microsomes[2].
AST5902 (0.003‑5 μM) modulates CYP3A4 mRNA expression in primary human hepatocytes, exhibiting weak to moderate CYP3A4 induction activity with an EC50 ranging from 0.13‑0.68 μM, and inhibits CYP3A4 mRNA transcription at low concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2412155-74-7
-
Molecular Weight 554.57
-
Formula C27H29F3N8O2
-
SMILES
C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AST5902 Related Classifications
HY-138627 Related Classifications
Powered by Bioz