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AICAR phosphate

(別名: Acadesine phosphate; AICA Riboside phosphate)
226 Cited Publications
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Based on 226 publication(s) in Google Scholar

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor.

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  • 純度: 99.97%
  • CAS 番号: 681006-28-0
  • 分子式: C9H17N4O9P
  • 分子量:356.23
  • 保管条件:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • AICAR phosphate Chemical Structure
    AICAR phosphate 構造式
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
CAS 番号: 681006-28-0
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  • AICAR phosphate Chemical Structure
    AICAR phosphate Chemical Structure
    1/16
  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2024 Jan;40(1-3):16-39. [Abstract]

    Customer Validation
     AICAR (0.5 mM; 12 h) significantly increases the expression of Mfn2 in BUMPT Cells.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 May 1;9(5):515. [Abstract]

    Customer Validation
     Protein expression levels of AMPKα, p-AMPKα-thr172, p-ACC-ser79, LC3, Beclin-1, ATG5 and ATG7 in WT MSCs or control CrispCas MSCs, or AMPKα DKO MSCs before and after treatment with FAC or AICAR.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     Cells are treated with AICAR and AICAR (A++, 10 μM) + Compound C (C++, 1 μM) for 24 h, after which western blot analysis is performed.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     MC3T3-E1 cells are treated with AICAR (10 μM) in the presence or absence of 3-MA (5 mM) or CQ (10 μM) for 24 h, after which western blot analysis is conducted.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 16:9:345. [Abstract]

    Customer Validation
     AMP-activated protein kinase (AMPK) activation by AST blunts dysfunction of lipid metabolism and resistance in HepG2 cells. Representative bands of SREBP-1c nuclear protein and cytoplasmic proteins are visualized in the immunoblotting assay.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 16:9:345. [Abstract]

    Customer Validation
     AMP-activated protein kinase activation by AST inhibits the expression of sterol regulatory element binding protein-1c (SREBP-1c) and SREBP-1c related genes. AST promotes AMPKa1 mRNA expression, AMPKa2 mRNA expression, and suppresses the expression of SREBP-1c, and its downstream genes FAS, ACC1, and also AMPK downstream gene SCD1.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jul 16:9:761. [Abstract]

    Customer Validation
     Epithelial cells from colon tissue are extracted from mice in each group (n=6-8 per group) and protein level of p-AMPK (Thr172) and AMPKα1/2 are measured by western blot.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3723-3738. [Abstract]

    Customer Validation
     The effect of AICAR on the expression of AMPK, p-AMPK, mTOR, p-mTOR, and autophagy-related protein by Western blot analysis.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]

    Customer Validation
     Raw264.7 macrophages with serum deprivation are treated with 50 μM Rg1 for 48 h in absence or presence of compound C (10 mM) or AICAR (250 μM). Western blots of the protein expressions of Atg5, Beclin1, LC3, and p62/SQSMT1.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Dec;233(12):9701-9715. [Abstract]

    Customer Validation
     HUVECs are pretreated with Compound C (5, 10, or 20 μM) for 18 hr or AICAR (1, 2, or 4 mM) for 1 hr, and then exposed to LSS for 30 min.

  • AICAR phosphate