L-(+)-リジン
Based on 9 publication(s) in Google Scholar
L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 56-87-1
- 分子式: C6H14N2O2
- 分子量:146.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 L-Lysine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Amino Acids. 2024 Sep 18;56(1):56. [Abstract]
- Cell Biochem Biophys. 2025 May 30. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- J Anim Physiol Anim Nutr. 2022 Nov;106(6):1420-1430. [Abstract]
- iMetaOmics. 2025 Aug 06.
- Patent. US20240216332A1.
- Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.
Customer Validation & Images
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In Vivo Efficacy Study
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IF
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Cell Migration/Invasion Assay
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WB
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Microbiological Assay
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
158 μM
Compound: 5962
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Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells
Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells
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10.5281/zenodo.6782708 |
| HEK293 | EC50 |
158 μM
Compound: 5962
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Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
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10.5281/zenodo.6782708 |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:L-Arginine hydrochloride (HY-N0455A)-induced acute pancreatitis mice model[4]
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Dosage:10 mg/kg
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Administration:Oral gavage (p.o.), single dose, pre-treated or post-treated
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Result:Led to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p < 0.001).
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Animal Model:Lipopolysaccharide (HY-D1056) -induced mouse model[4]
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Oral gavage (p.o.), once daily for 45 days
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Result:Significantly reduced lipid peroxidation, total protein content, lung tissue wet/dry ratio, tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels, myeloperoxidase activity, as well as total cell, neutrophil, and lymphocyte counts. Increased the levels of reduced glutathione and the activities of glutathione peroxidase, superoxide dismutase, and catalase.
化学情報
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CAS 番号 56-87-1
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性状 Solid
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分子量 146.19
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分子式 C6H14N2O2
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Color Off-white to yellow
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SMILES
N[C@@H](CCCCN)C(O)=O
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別名
L-Lysine
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
Cell Biochem Biophys
FOXA1 Transcriptional Repression of PLSCR1 Inhibits Tongue Squamous Cell Carcinoma Progression. [Abstract]2025 May 30. PMID: 40445264 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
J Anim Physiol Anim Nutr
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis. [Abstract]2022 Nov;106(6):1420-1430. PMID: 35923149 -
L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.
L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.
L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.
L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.
L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.
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溶剤 & 溶解度
体外:
H2O : 100 mg/mL (684.04 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (684.04 mM); Clear solution
純度とドキュメンテーション
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データシート (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]
[2]. Santos AMD, et al. Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine. Acta Cir Bras. 2017 Apr;32(4):297-306. [Content Brief]
[3]. Zhang Y, et al. L-lysine ameliorates sepsis-induced acute lung injury in a lipopolysaccharide-induced mouse model. Biomed Pharmacother. 2019 Oct;118:109307. [Content Brief]
[4]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.8404 mL | 34.2021 mL | 68.4041 mL | 171.0103 mL |
| 5 mM | 1.3681 mL | 6.8404 mL | 13.6808 mL | 34.2021 mL | |
| 10 mM | 0.6840 mL | 3.4202 mL | 6.8404 mL | 17.1010 mL | |
| 15 mM | 0.4560 mL | 2.2801 mL | 4.5603 mL | 11.4007 mL | |
| 20 mM | 0.3420 mL | 1.7101 mL | 3.4202 mL | 8.5505 mL | |
| 25 mM | 0.2736 mL | 1.3681 mL | 2.7362 mL | 6.8404 mL | |
| 30 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL | |
| 40 mM | 0.1710 mL | 0.8551 mL | 1.7101 mL | 4.2753 mL | |
| 50 mM | 0.1368 mL | 0.6840 mL | 1.3681 mL | 3.4202 mL | |
| 60 mM | 0.1140 mL | 0.5700 mL | 1.1401 mL | 2.8502 mL | |
| 80 mM | 0.0855 mL | 0.4275 mL | 0.8551 mL | 2.1376 mL | |
| 100 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7101 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Lysine 関連分類
HY-N0469 関連分類
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