AD4
Based on 1 publication(s) in Google Scholar
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 2918262-09-4
- 分子式: C55H78N4O15
- 分子量:1035.23
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 AD4
MorePROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
IC50: 0.6 nM (PCLAF/KIAA0101)[1]
化学情報
-
CAS 番号 2918262-09-4
-
性状 Solid
-
分子量 1035.23
-
分子式 C55H78N4O15
-
Color Light yellow to yellow
-
SMILES
C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(C(CCCCCCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CCO[C@H]8O[C@@]9([H])[C@]%10%11[C@](CC[C@H]([C@]%10([H])CC[C@](O9)(OO%11)C)C)([H])[C@H]8C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Glia
Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia. [Abstract]2024 Feb;72(2):433-451. PMID: 37870193
溶剤 & 溶解度
DMSO : 100 mg/mL (96.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9660 mL | 4.8298 mL | 9.6597 mL | 24.1492 mL |
| 5 mM | 0.1932 mL | 0.9660 mL | 1.9319 mL | 4.8298 mL | |
| 10 mM | 0.0966 mL | 0.4830 mL | 0.9660 mL | 2.4149 mL | |
| 15 mM | 0.0644 mL | 0.3220 mL | 0.6440 mL | 1.6099 mL | |
| 20 mM | 0.0483 mL | 0.2415 mL | 0.4830 mL | 1.2075 mL | |
| 25 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9660 mL | |
| 30 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8050 mL | |
| 40 mM | 0.0241 mL | 0.1207 mL | 0.2415 mL | 0.6037 mL | |
| 50 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4830 mL | |
| 60 mM | 0.0161 mL | 0.0805 mL | 0.1610 mL | 0.4025 mL | |
| 80 mM | 0.0121 mL | 0.0604 mL | 0.1207 mL | 0.3019 mL |
AD4 関連分類
HY-149428 関連分類
Powered by Bioz