Apoptosis inducer 52
Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS). Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR)-dependent and -independent prostate cancers and leukemia.
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- 分子式: C22H15F6N3O2Se
- 分子量:546.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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- 純度とドキュメンテーション
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生物活性
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Caspase 3 |
Caspase-7 |
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Apoptosis inducer 52 (compoun a5) (1-100 μM; 48 h; LNCaP) inhibits LNCaP and nonmalignant HaCaT cells with IC50 values of 8.89 µM and 28.71 µM, respectively[1].
Apoptosis inducer 52 displays a remarkable antiproliferative activity toward the K-562 cell line from the leukemia subpanel[1].
Apoptosis inducer 52 (10 μM; 24-48 h; LNCaP) induces apoptosis in a time‐dependent.[1].
Apoptosis inducer 52 (10 μM; 48 h; LNCaP) arrests cell cycle in G0/G1 phase[1].
Apoptosis inducer 52 (10 μM; 48 h; LNCaP) increases expression of caspase 3, 8, 9 and upregulates BAX[1].
Apoptosis inducer 52 (10 μM; 12-24 h; LNCaP) marginally increases ROS production. The result suggest that apoptosis induction by Apoptosis inducer 52 may be ROS-independent[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP and HaCaT cells
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Concentration:1, 2.5, 5, 10, 25, 50, 100 μM
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Incubation Time:48 h
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Result:Cell viability decreased in a dose-dependent manner.
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Cell Line:LNCaP
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Concentration:10 μM
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Incubation Time:24, 48 h
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Result:The ratio of apoptotic cells increased significantly at the end of the 48 h.
Caspase 3/7 activity increased and phosphatidylserine externalization was observed.
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Cell Line:LNCaP
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Concentration:10 μM
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Incubation Time:48 h
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Result:Inhibited the cell cycle progression by arresting the cells in the G0/G1 phase.
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Cell Line:LNCaP
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Concentration:10 μM
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Incubation Time:48 h
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Result:Expression levels of pro-caspase 3, pro-caspase 9, caspase 3, caspase 9, caspase 8 increased, and BAX levels were upregulated.
化学情報
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分子量 546.32
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分子式 C22H15F6N3O2Se
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SMILES
O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)[Se]CC(NC3=CC=CC(C(F)(F)F)=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 52 関連分類
HY-179124 関連分類
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