Bafilomycin B1
Based on 1 publication(s) in Google Scholar
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.10%
- CAS 番号: 88899-56-3
- 分子式: C44H65NO13
- 分子量:815.99
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Bafilomycin B1
MoreAntibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
|
Macrolide |
Bafilomycin B1 (Compound BafB1) (1 nM, 24 h) significantly inhibits the chloroquine-induced death of cerebellar granule neurons[1].
Bafilomycin B1 (Compound BafB1) (0.1-10 nM, 48 h) does not induce SH-SY5Y cell death or apoptosis at concentration ≤ 1 nM and significantly attenuates chloroquine-induced cell death with the addition of 50 μM chloroquine[2].
Bafilomycin B1 (5-10 nM) significantly inhibits the [14C]oleate incorporation into cholesteryl esters in J774 cells incubated with [14C]oleate in the presence of oxidized LDL for 3 h[3].
Bafilomycin B1 (10-40 nM) significantly inhibits the surface binding, intracellular accumulation and degradation of oxidized 125I-LDL in J774 cells incubated with oxidized 125I-LDL at 37 °C[3].
Bafilomycin B1 (50 nM, 20 min) inhibits 74% of the degradation of the internalized oxidized 125I-LDL in J774 cells, suggesting Bafilomycin B1 inhibits the endosomal and lysosomal functions[3].
Bafilomycin B1 (50 nM, 60 min) causes a reduction of the cell surface receptors for oxidized LDL when incubated with oxidized 125I-LDL at 37 °C[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 88899-56-3
-
性状 Solid
-
分子量 815.99
-
分子式 C44H65NO13
-
Color Off-white to yellow
-
SMILES
O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
-
Structure Classification
-
Initial Source
Streptomyces halstedii K122
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
iScience
Erythrabyssin ll is identified as a late-stage autophagy inhibitor reversing chemoresistance and promoting apoptosis in ovarian cancer. [Abstract]2025 Nov 6;28(7):112801. PMID: 40881620
溶剤 & 溶解度
DMSO : 100 mg/mL (122.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Shacka, J. J., et al., (2006). Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy, 2(3), 228–230. [Content Brief]
[2]. Pivtoraiko, V. N., et al., (2010). Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry, 114(4), 1193–1204. [Content Brief]
[3]. Naganuma, S., et al., (1992). Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochimica et biophysica acta, 1126(1), 41–48. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2255 mL | 6.1275 mL | 12.2551 mL | 30.6376 mL |
| 5 mM | 0.2451 mL | 1.2255 mL | 2.4510 mL | 6.1275 mL | |
| 10 mM | 0.1226 mL | 0.6128 mL | 1.2255 mL | 3.0638 mL | |
| 15 mM | 0.0817 mL | 0.4085 mL | 0.8170 mL | 2.0425 mL | |
| 20 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5319 mL | |
| 25 mM | 0.0490 mL | 0.2451 mL | 0.4902 mL | 1.2255 mL | |
| 30 mM | 0.0409 mL | 0.2043 mL | 0.4085 mL | 1.0213 mL | |
| 40 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7659 mL | |
| 50 mM | 0.0245 mL | 0.1226 mL | 0.2451 mL | 0.6128 mL | |
| 60 mM | 0.0204 mL | 0.1021 mL | 0.2043 mL | 0.5106 mL | |
| 80 mM | 0.0153 mL | 0.0766 mL | 0.1532 mL | 0.3830 mL | |
| 100 mM | 0.0123 mL | 0.0613 mL | 0.1226 mL | 0.3064 mL |
Powered by Bioz