CDK2-IN-61
CDK2-IN-61 is a highly selective CDK2 inhibitor with a human IC50 of 0.25 nM. CDK2-IN-61 can be used in cancer-related research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2498658-20-9
- 分子式: C21H25N5O4S
- 分子量:443.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CDK2/cyclinE 0.25 nM (IC50) |
体外実験
CDK2-IN-61 (compound 4g) exhibits inhibitory activity against CDK2/cyclin E1 with an IC50 value of 0.25 nM, and shows 1200-fold, 1000-fold, and 230-fold selectivity over CDK1/cyclin B1, CDK4/cyclin D1, and CDK6/cyclin D1, respectively[1].
CDK2-IN-61 exhibits a potency of 670 nM in in vitro human whole blood assays; it shows excellent kinome-wide selectivity in a cell-free kinome screening panel containing 54 kinases; and it displays a clearance rate of 0.8 L/h/kg in cell-free human liver microsome assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 2498658-20-9
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分子量 443.52
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分子式 C21H25N5O4S
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SMILES
O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC)(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK2-IN-61 関連分類
HY-184884 関連分類
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