EphB4-IN-1
EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src, Abl1, Lck, and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer, such as non small cell lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1394837-94-5
- 分子式: C18H18N4O2
- 分子量:322.36
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
EGFR アイソフォーム固有の製品をすべて表示
More
生物活性
|
EPHB4 016-0.3 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MEF | IC50 |
0.93 μM
Compound: 7
|
Inhibition of human full length EphB4 expressed in MEF cells assessed as inhibition of human ephrin B2/FC chimera-stimulated receptor autophosphorylation
Inhibition of human full length EphB4 expressed in MEF cells assessed as inhibition of human ephrin B2/FC chimera-stimulated receptor autophosphorylation
|
[PMID: 24900387] |
EphB4-IN-1 (Compound 7) inhibits purified EphB4 kinase with an IC50 of 0.30 μM (30 μM ATP)[1].
EphB4-IN-1 inhibits purified EphB4 kinase with an IC50 of 0.16 μM in a radioactive ATP-based enzymatic assay with 1 μM ATP[1].
EphB4-IN-1 inhibits purified Src, Abl1, Lck, and EGFR kinases with IC50 values of 0.338 μM, 0.864 μM, 1.38 μM, and 1.62 μM respectively, does not inhibit IGF1R, and has higher affinity for EphB4 than these five kinases[1].
EphB4-IN-1 inhibits EphB4 autophosphorylation in Ephrin-B2/Fc-stimulated MEF cells expressing exogenous human EphB4 with an IC50 of 0.93 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1394837-94-5
-
分子量 322.36
-
分子式 C18H18N4O2
-
SMILES
O=C1C2=C(CCCC2)C3=C(N1C4=CC(O)=CC=C4C)N=CN=C3N
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
EphB4-IN-1 関連分類
HY-185227 関連分類
Powered by Bioz