製品番号: HY-N4327

Eurycomalactone

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Based on 1 Customer Validation

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

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純度: 99.74%
CAS 番号: 23062-24-0
分子式: C₁₉H₂₄O₆
分子量:348.39

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Eurycomalactone 構造式

CAS 番号: 23062-24-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 0.5 μM (NF-κB)^[1]

NF-κB アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.98 μM Compound: 11	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19919052]

体外実験

Eurycomalactone (24, 48 and 72 h) selectively inhibits the viability of A549 and COR-L23 cells Eurycomalactone inhibits the viability of A549 cells with IC₅₀ values of 20.17, 3.77, and 1.90 μM for 24, 48 and 72 hours, respectively. Eurycomalactone inhibits the viability of COR-L23 cells with IC₅₀ values of 25.02, 2.74, and 1.80 μM for 24, 48 and 72 hours, respectively^[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) promotes Non-small cell lung cancer (NSCLC) cells apoptosis^[2].
Eurycomalactone (0-25.05 μM; 24 h; A549 and COR-L23 cells) induces cell cycle arrest at the radiosensitive G2/M phase and induces apoptosis in irradiated Non-small cell lung cancer (NSCLC) cells. Eurycomalactone downregulated the key G2/M regulatory proteins in irradiated Non-small cell lung cancer (NSCLC) cells^[1].
Eurycomalactone (2.5-25 μM; 24 h; A549 cells) suppressed the repair of radiation-Induced DNA double-strand breaks^[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) suppresses AKT/NF-κB activation in Non-small cell lung cancer (NSCLC) cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

A549 and Calu-1 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

Increased the apoptotic rates in a dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

A549 and COR-L23 cells
Concentration:

1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:

24 hours
Result:

Induced cell cycle arrest at G2/M phase in irradiated cells and increased the sub-G1 population. A549 and COR-L23 cells

Western Blot Analysis^[2]

Cell Line:

A549 and Calu-1 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

Induced the expression levels of active caspase-3 and active PARP (cleaved form), while decreased Bcl-xL and surviving.

Western Blot Analysis^[1]

Cell Line:

A549 and COR-L23 cells
Concentration:

1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:

24 hours
Result:

Downregulated the expression of both G2/M regulatory proteins in a dose-dependent manner.

Western Blot Analysis^[2]

Cell Line:

A549 and COR-L23 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

inhibited the expression levels of p^(S473)-AKT, total AKT, p^(S536)-NF-κB p65 and total NF-κB p65.

化学情報

CAS 番号 23062-24-0
性状 Solid
分子量 348.39
分子式 C₁₉H₂₄O₆
Color White to off-white
SMILES

C[C@]12[C@@]([C@H]([C@@](O3)([H])[C@@](C)([H])[C@]2([H])C3=O)O)([H])[C@]([C@@](C(C)=CC4=O)([H])CC1=O)([C@@H]4O)C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- other families
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (287.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8703 mL

14.3517 mL

28.7035 mL

5 mM

0.5741 mL

2.8703 mL

5.7407 mL

10 mM

0.2870 mL

1.4352 mL

2.8703 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (288 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. [Content Brief]

[2]. Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. [Content Brief]

[3]. Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8703 mL	14.3517 mL	28.7035 mL	71.7587 mL
	5 mM	0.5741 mL	2.8703 mL	5.7407 mL	14.3517 mL
	10 mM	0.2870 mL	1.4352 mL	2.8703 mL	7.1759 mL
	15 mM	0.1914 mL	0.9568 mL	1.9136 mL	4.7839 mL
	20 mM	0.1435 mL	0.7176 mL	1.4352 mL	3.5879 mL
	25 mM	0.1148 mL	0.5741 mL	1.1481 mL	2.8703 mL
	30 mM	0.0957 mL	0.4784 mL	0.9568 mL	2.3920 mL
	40 mM	0.0718 mL	0.3588 mL	0.7176 mL	1.7940 mL
	50 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	60 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1960 mL
	80 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8970 mL
	100 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7176 mL

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Eurycomalactone

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NF-κB アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

Bcl-2 Family アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Eurycomalactone 関連分類

HY-N4327 関連分類