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製品番号: HY-149373

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Garcinone B

Garcinone B is an NF-κB inhibitor. Garcinone B inhibits LPS-induced NF-κB-dependent transcriptional activation, NF-κB expression, NF-κB-mediated transcription, and IKK, prevents COX-2 transcription, and contributes to immune regulation. Garcinone B inhibits COX enzymes, inhibits prostaglandin E₂ release, and contributes to anti-inflammation. Garcinone B blocks ACE2-spike binding, prevents viral entry, inhibits M^pro, and prevents polyprotein cleavage and replication. Garcinone B has antibacterial activity against cariogenic bacteria and bactericidal activity against S. mutans. Garcinone B can be used for research on COVID-19, tuberculosis, and dental caries.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 76996-28-6
分子式: C₂₃H₂₂O₆
分子量:394.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Garcinone B 構造式

CAS 番号: 76996-28-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]

NF-κB

IKK

COX-2

prostaglandin E2

ACE2

Mpro

NF-κB アイソフォーム固有の製品をすべて表示 :

COX アイソフォーム固有の製品をすべて表示 :

IKK アイソフォーム固有の製品をすべて表示 :

体外実験

Bacterial InfectionInnate ImmunityLipid Inflammatory MediatorsLipid mediators of inflammationAnti-cancer

Bacterial Infection

Garcinone B (6.25 μg/mL) inhibits Mycobacterium tuberculosis in vitro, with an MIC of 6.25 μg/mL^[3].
Garcinone B inhibits cariogenic bacteria, with an MIC of 0.25 µg/mL against S. mutans, S. sobrinus, and S. mutans ATCC 25175, and an MIC of 0.5 µg/mL against L. acidophilus and L. casei^[5].
Garcinone B (1-2 µg/mL; sampled at 0-24 h; plated at 48 h) exerts a bactericidal effect on S. mutans ATCC 25175, achieving bactericidal activity at 1 µg/mL and completely killing the bacteria within 1 h at 2 µg/mL^[5].
Garcinone B reduces the cell surface hydrophobicity of S. mutans ATCC 25175 from 90% to 23%^[5].

Innate Immunity

Garcinone B (20 μM; 3 h) inhibits LPS-induced NF-κB-dependent transcription by approximately 30% in C6 rat glioma cells^[1].

Innate Immunity

Lipid Inflammatory Mediators

Garcinone B exerts anti-inflammatory activity in LPS-treated C6 rat glioma cells through the same mechanism as γ-mangostin (Gamma-Mangostin) (HY-N1957), involving the IKK/COX-2 signaling pathway^[3].
Garcinone B inhibits A23187-induced PGE₂ release in C6 rat glioma cells and inhibits LPS-induced NF-κB transcriptional activation^[4].

Lipid mediators of inflammation

Anti-cancer

Garcinone B (10 μM; 10 min) reduces A23187-induced PGE₂ release by 30% in C6 rat glioma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 76996-28-6
分子量 394.42
分子式 C₂₃H₂₂O₆
SMILES

OC(C(C/C=C(C)/C)=C1O)=CC2=C1C(C3=C4C(OC(C)(C)C=C4)=C(O)C=C3O2)=O
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yamakuni T, et al. Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells. Neuroscience letters. 2006 Feb 20;394(3):206-10.

[2]. Suhandi C, et al. Potency of Xanthone Derivatives from L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A Computational Study. Molecules (Basel, Switzerland). 2023 Jul 04;28(13):5187. [Content Brief]

[3]. Chin YW, et al. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement. Mini-reviews in organic chemistry. 2008 Nov 01;5(4):355-364.

[4]. Liu QY, et al. New insights into the anti-obesity activity of xanthones from Garcinia mangostana. Food & function. 2015 Feb 1;6(2):383-93.

[5]. Aroonrerk N, et al. Anticariogenic activity of Garcinone B from Garcinia mangostana. SWU Dent J. 2021 Nov 30;14(2):25-34.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
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- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Garcinone B

NF-κB アイソフォーム固有の製品をすべて表示

COX アイソフォーム固有の製品をすべて表示

IKK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Garcinone B 関連分類

HY-149373 関連分類

Bioz

Keywords

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