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製品番号: HY-145688

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HDAC-IN-33

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

HDAC-IN-33 is a potent HDAC inhibitor with IC₅₀s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity.

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CAS 番号: 2766688-19-9
分子式: C₂₁H₂₅N₃O₃
分子量:367.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

HDAC-IN-33 構造式

CAS 番号: 2766688-19-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	3.97 μM Compound: 9l	Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
HEL	IC₅₀	0.36 μM Compound: 9l	Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
HepG2	IC₅₀	4.8 μM Compound: 9l	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
K562	IC₅₀	0.99 μM Compound: 9l	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
KG-1	IC₅₀	3.4 μM Compound: 9l	Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
PC-3	IC₅₀	7.9 μM Compound: 9l	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]

体外実験

HDAC-IN-33 (Compound 9l) shows good in vivo antitumor efficacies in both HEL xenograft model and murine melanoma model. HDAC-IN-33 promotes the antigen presentation and activate T cells, thereby triggering antitumor immunity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2766688-19-9
分子量 367.44
分子式 C₂₁H₂₅N₃O₃
SMILES

O=C(NO)CCCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. "Chen C, et al. Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. J Med Chem. 2022 Feb 24;65(4):3667-3683. " [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HDAC-IN-33

1 Cited Publications

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生物活性
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化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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HDAC-IN-33

MedChemExpress（MCE）の使用を引用している文献 HDAC-IN-33

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HDAC-IN-33 関連分類

HY-145688 関連分類