Hericene A
Based on 1 Customer Validation
Hericene A is an orally active aromatic hericene derivative. Hericene A exhibits anti-inflammatory and neurotrophic activities, and can found in the fruiting bodies of Hericium erinaceus. Hericene A inhibits the secretion of pro-inflammatory mediators. Hericene A promotes axonal growth, neurite branching, neurotrophic factor expression and downstream signal transduction. Hericene A can be used for the research of inflammatory and neurological diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.84%
- CAS 番号: 157207-54-0
- 分子式: C35H56O5
- 分子量:556.82
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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IL-6 |
Hericene A (0.5-100 μM; 2 h pretreatment) inhibits LPS (HY-D1056)-induced secretion of TNF-α, IL-6 and NO in mouse RAW 264.7 macrophages, with IC50 values of 78.50 µM, 56.33 µM and 87.31 µM, respectively, and does not reduce cell viability at the tested concentrations[1].
Hericene A (10 μg/mL; 24 h) potently promotes axonal growth in primary hippocampal neurons isolated from E18 Sprague Dawley rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophage cells treated LPS
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Concentration:0.5, 1, 5, 10, 50, 100 μM
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Incubation Time:2 h pretreatment + 24 h LPS stimulation
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Result:Inhibited IL-6 and NO production in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 6 weeks old, 23-25 g)[2]
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Dosage:5 mg/kg
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Administration:p.o.; daily; 31 days
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Result:Increased brain levels of neurotrophins BDNF, NGF, CNTF, and GDNF.
Increased phosphorylation of neurotrophin receptors TrkB and TrkA.
Increased activation of downstream signaling molecules ERK1/2 and CREB.
Increased levels of synaptophysin (SYP), a synaptic marker.
Increased BDNF immunoreactivity in the dentate gyrus of the hippocampus and cortical regions.
Significantly enhanced novel object recognition performance.
Significantly enhanced spontaneous alternation behavior in the Y-maze test.
化学情報
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CAS 番号 157207-54-0
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性状 Solid
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分子量 556.82
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分子式 C35H56O5
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC/C=C(C)\C)C=O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (267 KB)
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SDS (252 KB)
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- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Xie G, et al. Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities. Molecules. 2022 Mar 27;27(7):2157. [Content Brief]
[2]. Martínez-Mármol R, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. 2023;165(6):791-808. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Hericene A 関連分類
HY-N16499 関連分類
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