Hypocrellin B
Based on 1 publication(s) in Google Scholar
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities.
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- 純度: 99.50%
- CAS 番号: 123940-54-5
- 分子式: C30H24O9
- 分子量:528.51
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Hypocrellin B
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生物活性
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Leishmania |
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Cell Line
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Type | Value | Description | References |
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| BGC-823 | IC50 |
40 nM
Compound: 2
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Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
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[PMID: 22352922] |
Hypocrellin B (2.5 μM, 4 h) induces cell cytotoxicity 24 h after sonodynamic therapy (SDT) in HepG2 cells, and induces induce the early apoptosis[2].
Hypocrellin B shows antifungal and anti-parasite activity against C. albicans and Leishmania donovani respectively (IC50: 5 and 12.7 μg/mL)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 123940-54-5
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性状 Solid
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分子量 528.51
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分子式 C30H24O9
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Color Brown to black
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SMILES
CC(C1)=C(C(C)=O)C(C2=C(C3=C(O)C=C4OC)C4=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C3=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* Hypocrellin B is usually formulated as a suspension.
純度とドキュメンテーション
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データシート (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Miller GG, et al. Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update. Photochem Photobiol. 1997 Apr;65(4):714-22. [Content Brief]
[2]. Wang X, et al. Hypocrellin B-mediated sonodynamic action induces apoptosis of hepatocellular carcinoma cells. Ultrasonics. 2012 Apr;52(4):543-6. [Content Brief]
[3]. Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48(11):4450-2. [Content Brief]
[4]. Chang JE, et al. Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer. J Photochem Photobiol B. 2016 May;158:113-21. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Hypocrellin B 関連分類
HY-N1453 関連分類
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