L1BC8
Based on 1 Customer Validation
L1BC8 (Compound 13a) is a drug-linker conjugate for ADC. L1BC8 is obtained by conjugating a BRD4 PROTAC degrader with a peptidomimetic protease-cleavable linker for the preparation of ADC, which can be conjugated to STEAP1 antibodies and CLL1 antibodies, respectively. L1BC8 can be used in research related to prostate cancer and acute myeloid leukemia.
(Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.20%
- CAS 番号: 2417370-68-2
- 分子式: C86H98F2N16O18S2
- 分子量:1745.92
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
BRD4 |
体外実験
The drug-linker conjugate of an antibody-drug conjugate (ADC) consists of an active cytotoxic drug and an appropriate linker. These conjugates, when linked to a monoclonal antibody, can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.
PROTAC stands for proteolysis-targeting chimeras, a type of heterobifunctional small molecule compound containing two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "three-body" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase closer together. PROTACs can improve the druggability of "undruggable" targets.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2417370-68-2
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性状 Solid
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分子量 1745.92
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分子式 C86H98F2N16O18S2
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Color White to off-white
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SMILES
O=C(OCC1=CC=C(NC([C@@H](NC(C2(CCC2)C(NCCCCCN3C(C=CC3=O)=O)=O)=O)CCCNC(N)=O)=O)C=C1)NC4=CC(CCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=CC(OCCNC(C8=C(CS(=O)(C)=O)C=C(C(N(C9=NC=C(F)C=C9F)C%10)=C8)C%11=CN(C)C(C%12=C%11C%10=CN%12)=O)=O)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L1BC8 関連分類
HY-164995 関連分類
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