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United States

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製品番号: HY-182486

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LEM-06

LEM-06 is an NSD2 inhibitor with a human IC₅₀ of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2-SET, inhibiting NSD2-mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.

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CAS 番号: 1212675-57-4
分子式: C₂₉H₃₈N₄O₃
分子量:490.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEM-06 構造式

CAS 番号: 1212675-57-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

NSD2

890 μM (IC₅₀)

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

体外実験

LEM-06 inhibits the H3K36 monomethylation activity of recombinant NSD2-SET protein in vitro, with an IC₅₀ value of 890 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 1212675-57-4
分子量 490.64
分子式 C₂₉H₃₈N₄O₃
SMILES

O=C1N2C([C@@]3([H])CN(C4CCN(CC4)C(C)=O)C[C@@](C3)([H])C2)=CC=C1C5=C(C=CC=C5)CN6CCOCC6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. di Luccio E, et al. Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies. J Cancer Prev. 2015;20(2):113-120. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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