ML234
ML234 is a dual inhibitor against EZH2/LSD1 with IC50 values of 0.09 and 0.12 μM, respectively. ML234 displays an excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3 and 22RV1. ML234 suppresses the tumor growth in the 22RV1 xenograft mouse model. ML234 is promising for research of anticancer agents in prostate cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3068378-07-1
- 分子式: C43H58N4O6
- 分子量:726.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | GI50 |
3.96 μM
Compound: 9j; ML234
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Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
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[PMID: 39196854] |
| LNCaP | GI50 |
1.63 μM
Compound: 9j; ML234
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Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
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[PMID: 39196854] |
| PC-3 | GI50 |
1.04 μM
Compound: 9j; ML234
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Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
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[PMID: 39196854] |
化学情報
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CAS 番号 3068378-07-1
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分子量 726.94
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分子式 C43H58N4O6
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SMILES
CC(C(C(NCC1=C(C=C(NC1=O)C)C)=O)=CC(C2=CC=C([C@@H]3C[C@H]3N(C(OC(C)(C)C)=O)CC4CCOCC4)C=C2)=C5)=C5N(CC)C6CCOCC6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ML234 関連分類
HY-169078 関連分類
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