Moxalactam
Based on 1 publication(s) in Google Scholar
Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 64952-97-2
- 分子式: C20H20N6O9S
- 分子量:520.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Moxalactam
MoreBeta-lactamase アイソフォーム固有の製品をすべて表示
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生物活性
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β-lactam |
Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL[1].
Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam[1].
Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old male strain ICR mice, weighing 18-20 g, bacterial infection model[2]
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Dosage:0-7.4 mg/mouse
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Administration:Subcutaneous injection, once
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Result:Showed protective activity with ED50s less than 7.4 mg/mouse against gram-positive and gram-negative bacterial infected mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 64952-97-2
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分子量 520.47
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分子式 C20H20N6O9S
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SMILES
O=C(C(N12)=C(CSC3=NN=NN3C)CO[C@]2([H])[C@](OC)(NC(C(C(O)=O)C4=CC=C(O)C=C4)=O)C1=O)O
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別名
Latamoxef; Lamoxactam; LY-127935
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Moxalactam 関連分類
HY-B1484A 関連分類
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