MRS 1477
MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 212200-21-0
- 分子式: C21H27NO4S
- 分子量:389.51
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | IC50 |
10.6 μM
Compound: 7; MRS1477
|
Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 37000154] |
| MCF7 | IC50 |
3 μM
Compound: 7; MRS1477
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 37000154] |
| MDA-MB-231 | IC50 |
40.8 μM
Compound: 7; MRS1477
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 37000154] |
| NIH3T3 | EC50 |
21.3 μM
Compound: 23, MRS-1477
|
Agonist-enhancing activity in epsilon-epitope tagged TRPV1 receptor expressed in mouse NIH3T3 cells assessed as capsaicin-induced 45Ca2+ influx by microplate liquid scintillation counter
Agonist-enhancing activity in epsilon-epitope tagged TRPV1 receptor expressed in mouse NIH3T3 cells assessed as capsaicin-induced 45Ca2+ influx by microplate liquid scintillation counter
|
[PMID: 18809334] |
MRS1477 evokes Ca2+ signals in MCF7 breast cancer cells, but not in primary breast epithelial cells[1].
MRS1477 (2 μM; 72 h) with capsaicine (10 μM) induces apoptosis and increases reactive oxygen species production and caspase activity[1].
MRS1477 (2 μM) increases capsaicin-evoked TRPV1-mediated current density levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 212200-21-0
-
分子量 389.51
-
分子式 C21H27NO4S
-
SMILES
CCOC(C1=C(C2=CC=CC=C2)NC(C)=C(C(SCCOC)=O)C1CC)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950. [Content Brief]
[2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MRS 1477 関連分類
HY-110145 関連分類
Powered by Bioz