Nemonapride
Based on 1 Customer Validation
Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 75272-39-8
- 分子式: C21H26ClN3O2
- 分子量:387.90
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-HT1A Receptor 34 nM (IC50) |
5-HT1A Receptor |
D2 Receptor 0.06 nM (Ki) |
化学情報
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CAS 番号 75272-39-8
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性状 Solid
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分子量 387.90
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分子式 C21H26ClN3O2
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Color White to off-white
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SMILES
O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC
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別名
YM-09151-2; Emonapride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMF : 20 mg/mL (51.56 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Terai M, et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol. 1983 Aug;33(4):749-55. [Content Brief]
[2]. Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. [Content Brief]
[3]. Assié MB, et al. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur J Pharmacol. 1997 Sep 10;334(2-3):141-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.5780 mL | 12.8899 mL | 25.7798 mL | 64.4496 mL |
| 5 mM | 0.5156 mL | 2.5780 mL | 5.1560 mL | 12.8899 mL | |
| 10 mM | 0.2578 mL | 1.2890 mL | 2.5780 mL | 6.4450 mL | |
| 15 mM | 0.1719 mL | 0.8593 mL | 1.7187 mL | 4.2966 mL | |
| 20 mM | 0.1289 mL | 0.6445 mL | 1.2890 mL | 3.2225 mL | |
| 25 mM | 0.1031 mL | 0.5156 mL | 1.0312 mL | 2.5780 mL | |
| 30 mM | 0.0859 mL | 0.4297 mL | 0.8593 mL | 2.1483 mL | |
| 40 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6112 mL | |
| 50 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2890 mL |
Nemonapride 関連分類
HY-103415 関連分類
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