Palvanil
Based on 1 Customer Validation
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 69693-13-6
- 分子式: C24H41NO3
- 分子量:391.59
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EFM-19 | IC50 |
1 μM
Compound: 3
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Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| MCF7 | IC50 |
2.2 μM
Compound: 3
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Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| T47D | IC50 |
1.6 μM
Compound: 3
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Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in HEK-293 intracellular[1].
Palvanil (1-10 nM; 5 min) treatment desensitizes TRPV1 to the effect of Capsaicin significantly[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-293 cells
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Concentration:0.1, 0.5, 1, 5, 10, 50, 100 and 1000 nM
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Incubation Time:0-300 min
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Result:Produced a dose-dependent increase in intracellular calcium with a EC50 of 0.65 nM.
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Cell Line:HEK-293-TPRV1 cells
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Concentration:1-10 nM
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Incubation Time:5 min
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Result:Desensitized TRPV1 to the effect of Capsaicin significantly (IC50=0.81 nM).
Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation[2].
Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in spared nerve injury (SNI) mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice[2]
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Dosage:1 or 10 mg/kg
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Administration:Subcutaneous injection; 1 or 10 mg/kg; once
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Result:Led to a slight and short lasting hypothermic effect, produced late hyperthermia.
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Animal Model:Female BALB/C mice[2]
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Dosage:100 μL (15 nM) per mouse
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Administration:Intraperitoneal injection; 100 μL (15 nM) per mouse; once
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Result:Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s).
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Animal Model:Male CD-1 mice received formalin[2]
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Dosage:0.5, 0.75, and 1 mg/kg
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Administration:Intravenous injection; 0.5, 0.75, and 1 mg/kg; once
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Result:Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner.
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Animal Model:Male C57BL/6J mice with acute inflammation induced by Carrageenan[2]
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Dosage:2.5 mg/kg
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Administration:Intravenous injection; 2.5 mg/kg; once
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Result:Reduced the volume of the oedema in the ipsilateral hind paw (64%).
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Animal Model:Male CD-1 mice[2]
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Dosage:0.5 and 1 mg/kg
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Administration:Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days
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Result:Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
化学情報
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CAS 番号 69693-13-6
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性状 Solid
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分子量 391.59
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分子式 C24H41NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (63.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Luciano De Petrocellis, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011 Apr;63(4):294-9. [Content Brief]
[2]. Livio Luongo, et al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012 Sep;66(3):243-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5537 mL | 12.7685 mL | 25.5369 mL | 63.8423 mL |
| 5 mM | 0.5107 mL | 2.5537 mL | 5.1074 mL | 12.7685 mL | |
| 10 mM | 0.2554 mL | 1.2768 mL | 2.5537 mL | 6.3842 mL | |
| 15 mM | 0.1702 mL | 0.8512 mL | 1.7025 mL | 4.2562 mL | |
| 20 mM | 0.1277 mL | 0.6384 mL | 1.2768 mL | 3.1921 mL | |
| 25 mM | 0.1021 mL | 0.5107 mL | 1.0215 mL | 2.5537 mL | |
| 30 mM | 0.0851 mL | 0.4256 mL | 0.8512 mL | 2.1281 mL | |
| 40 mM | 0.0638 mL | 0.3192 mL | 0.6384 mL | 1.5961 mL | |
| 50 mM | 0.0511 mL | 0.2554 mL | 0.5107 mL | 1.2768 mL | |
| 60 mM | 0.0426 mL | 0.2128 mL | 0.4256 mL | 1.0640 mL |
Palvanil 関連分類
HY-137988 関連分類
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