PD-M6
Based on 1 Customer Validation
PD-M6 is a mTOR PROTAC degrader (DC50: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer.
(Pink: mTOR ligand (HY-B0795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W008296)).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.17%
- CAS 番号: 3058330-82-5
- 分子式: C30H39N9O6
- 分子量:621.69
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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PI3K/Akt/mTOR Compound Library
HY-L015
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Oxygen Sensing Compound Library
HY-L045
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Glycolysis Compound Library
HY-L058
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Cytoskeleton Compound Library
HY-L060
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
HY-L083
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Angiogenesis-Related Compound Library
HY-L088
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Glucose Metabolism Compound Library
HY-L092
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Anti-Liver Cancer Compound Library
HY-L101
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Pain-Related Compound Library
HY-L139
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PROTAC Library
HY-L151
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Cell Death Library
HY-L162
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
PD-M6 (0.001-10 μM; 4-24 h) induces dose- and time-dependent degradation of mTOR in HeLa cells, with a DC50 of 4.8 μM[1].
PD-M6 inhibits the proliferation of HeLa, MCF-7 and HepG2 cancer cells, with IC50 values of 11.3 μM, 2.58 μM and 3.23 μM, respectively[1].
PD-M6 (0.1-10 μM; 4 days) inhibits long-term colony formation of HeLa cells[1].
PD-M6 (10 μM) inhibits the migration of HeLa cells with an inhibition rate of over 50%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0.001-10 μM
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Incubation Time:4 h, 12 h, 24 h
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Result:Induced a dose-dependent reduction in mTOR levels, with significant degradation observed at 1 μM and maximum degradation (~90%) at 10 μM after 12 h.
Achieved a DC50 for mTOR degradation of 4.8 μM.
Reduced mTOR levels by ~50% at 4 h and ~90% at 24 h at 10 μM.
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Cell Line:HeLa cells
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Concentration:0.1-10 μM
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Incubation Time:4 days
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Result:Reduced HeLa cell colony formation in a concentration-dependent manner, with nearly 90% suppression of proliferation observed at 10 μM.
化学情報
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CAS 番号 3058330-82-5
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性状 Solid
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分子量 621.69
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分子式 C30H39N9O6
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Color Light yellow to yellow
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SMILES
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (160.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6085 mL | 8.0426 mL | 16.0852 mL | 40.2130 mL |
| 5 mM | 0.3217 mL | 1.6085 mL | 3.2170 mL | 8.0426 mL | |
| 10 mM | 0.1609 mL | 0.8043 mL | 1.6085 mL | 4.0213 mL | |
| 15 mM | 0.1072 mL | 0.5362 mL | 1.0723 mL | 2.6809 mL | |
| 20 mM | 0.0804 mL | 0.4021 mL | 0.8043 mL | 2.0106 mL | |
| 25 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6085 mL | |
| 30 mM | 0.0536 mL | 0.2681 mL | 0.5362 mL | 1.3404 mL | |
| 40 mM | 0.0402 mL | 0.2011 mL | 0.4021 mL | 1.0053 mL | |
| 50 mM | 0.0322 mL | 0.1609 mL | 0.3217 mL | 0.8043 mL | |
| 60 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6702 mL | |
| 80 mM | 0.0201 mL | 0.1005 mL | 0.2011 mL | 0.5027 mL | |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1609 mL | 0.4021 mL |
PD-M6 関連分類
HY-176166 関連分類
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