Peplomycin
Peplomycin (Bleomycin PEP) is an analog of Bleomycin (HY-108345) and an antitumor antibiotic. Peplomycin exhibits potent antitumor activity and relatively low pulmonary toxicity. Peplomycin can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma. Peplomycin can also induce pulmonary fibrosis. Peplomycin is applicable for the research of tumors, pulmonary fibrosis and other related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 68247-85-8
- 分子式: C61H88N18O21S2
- 分子量:1473.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Peplomycin (0-100 μM; 30 h) inhibits human oral squamous carcinoma cell line SSCKN and SCCTF cells in a dose-dependent manner[3].
Peplomycin (1 μM and 10 μM; 30 h) results nuclear fragmentation and condensation of chromatin in cells dose-dependently and induces apoptosis[3].
Peplomycin (5 mg/mL; 7 d) induces pulmonary fibrosis separated from saline-injected rats (N-Fib) by differentiating fibroblasts to alpha-SMA-positive MF[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SSCKN and SCCTF cells
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Concentration:0, 1, 5, 10, 50, and 100 μM
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Incubation Time:30 hours
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Result:Decreased SSCKN and SCCTF cells viability dose-dependently up to 50 μM, and resulted the viability of 38% and 30% that of the control group, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 68247-85-8
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分子量 1473.59
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分子式 C61H88N18O21S2
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SMILES
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O
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別名
Bleomycin PEP; Pepleomycin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11(4):303-5. [Content Brief]
[2]. Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150(6):1213-4. [Content Brief]
[3]. Okamura H, et al. Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity. Oral Oncol. 2001 Jun;37(4):379-85. [Content Brief]
[4]. Osaki T, et al. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001 Aug;82(4):231-41. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Peplomycin 関連分類
HY-106364 関連分類
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