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Picankibart

(別名: IBI112)
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Based on 1 Customer Validation

Picankibart (IBI112) is a monoclonal antibody targeting IL-23p19. Picankibart has a Kd of 4.806-12 M for human IL-23p19, with an EC50 of 1.4632 nM and an IC50 of 1.2533 nM. Picankibart binds to the IL-23 p19 subunit, blocks the binding of IL-23 to the IL-23 receptor, and inhibits downstream STAT3 phosphorylation and IL-17 production. Picankibart can be used in research on psoriasis and ulcerative colitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度 : 98.00%
  • CAS 番号: 2622900-74-5
  • 分子量:144.744 kDa
  • 保管条件:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Picankibart
  • Experimental Validation Results for Picankibart
  • Experimental Validation Results for Picankibart
  • Picankibart Chemical Structure
    Picankibart 構造式
CAS 番号: 2622900-74-5
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Picankibart on AHC2 biosensor, can bind Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His, HY-P74874) with an affinity constant of 7.207E-11 M as determined in BLI assay.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling IL-23A (red) with Picankibart (anti-IL-23A) (HY-P990057). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Picankibart Chemical Structure
    1/16
  • Picankibart
  • Loaded Picankibart on AHC2 biosensor, can bind Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His, HY-P74874) with an affinity constant of 7.207E-11 M as determined in BLI assay.
  • Flow Cytometry analysis of Raji cells labelling IL-23A (red) with Picankibart (anti-IL-23A) (HY-P990057). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).