(S)-Hydroxychloroquine
Based on 2 publication(s) in Google Scholar
(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine. Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro.
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- CAS 番号: 137433-24-0
- 分子式: C18H26ClN3O
- 分子量:335.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (S)-Hydroxychloroquine
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生物活性
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Plasmodium |
TLR7 |
TLR9 |
化学情報
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CAS 番号 137433-24-0
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分子量 335.87
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分子式 C18H26ClN3O
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SMILES
CCN(CCO)CCC[C@@H](NC1=CC=NC2=CC(Cl)=CC=C12)C
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別名
(S)-HCQ
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway. [Abstract]2026 Feb:244:117624. PMID: 41360230 -
J Cell Mol Med
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway. [Abstract]2022 May;26(10):2981-2994. PMID: 35429093
純度とドキュメンテーション
参考文献
[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8. [Content Brief]
[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]
[3]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]
[4]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(S)-Hydroxychloroquine 関連分類
HY-B1370A 関連分類
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