Serotonin-d4
Based on 1 publication(s) in Google Scholar
Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
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- 純度: 99.61%
- CAS 番号: 58264-95-2
- 分子式: C10H8D4N2O
- 分子量:180.24
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Serotonin-d4
More5-HT Receptor アイソフォーム固有の製品をすべて表示
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 58264-95-2
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非標識Cas 50-67-9
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性状 Solid
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分子量 180.24
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分子式 C10H8D4N2O
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Color Light brown to brown
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SMILES
NC([2H])([2H])C([2H])([2H])C(C1=C2)=CNC1=CC=C2O
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別名
5-Hydroxytryptamine-d4; 5-HT-d4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease. [Abstract]2026 May 13:S1550-4131(26)00150-6. PMID: 42134325
溶剤 & 溶解度
DMSO : 100 mg/mL (554.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25. [Content Brief]
[3]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5482 mL | 27.7408 mL | 55.4816 mL | 138.7039 mL |
| 5 mM | 1.1096 mL | 5.5482 mL | 11.0963 mL | 27.7408 mL | |
| 10 mM | 0.5548 mL | 2.7741 mL | 5.5482 mL | 13.8704 mL | |
| 15 mM | 0.3699 mL | 1.8494 mL | 3.6988 mL | 9.2469 mL | |
| 20 mM | 0.2774 mL | 1.3870 mL | 2.7741 mL | 6.9352 mL | |
| 25 mM | 0.2219 mL | 1.1096 mL | 2.2193 mL | 5.5482 mL | |
| 30 mM | 0.1849 mL | 0.9247 mL | 1.8494 mL | 4.6235 mL | |
| 40 mM | 0.1387 mL | 0.6935 mL | 1.3870 mL | 3.4676 mL | |
| 50 mM | 0.1110 mL | 0.5548 mL | 1.1096 mL | 2.7741 mL | |
| 60 mM | 0.0925 mL | 0.4623 mL | 0.9247 mL | 2.3117 mL | |
| 80 mM | 0.0694 mL | 0.3468 mL | 0.6935 mL | 1.7338 mL | |
| 100 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3870 mL |
Serotonin-d4 関連分類
HY-B1473AS 関連分類
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