TEC 4
Based on 1 Customer Validation
TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad (HY-78695); Blue: Rpn-13 ligand (HY-159808); Black: linker (HY-W008352).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- 分子式: C48H51BrCl2N10O6S2
- 分子量:1078.92
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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性状 Solid
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分子量 1078.92
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分子式 C48H51BrCl2N10O6S2
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Color White to off-white
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SMILES
BrC1=CC=C(CC2=NN=C(N2N=C3C4=CC=C(C=C4)Cl)SC3CC(NCCOCCOCCOCCOCCNC(C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C)=O)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (92.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9269 mL | 4.6343 mL | 9.2685 mL | 23.1713 mL |
| 5 mM | 0.1854 mL | 0.9269 mL | 1.8537 mL | 4.6343 mL | |
| 10 mM | 0.0927 mL | 0.4634 mL | 0.9269 mL | 2.3171 mL | |
| 15 mM | 0.0618 mL | 0.3090 mL | 0.6179 mL | 1.5448 mL | |
| 20 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1586 mL | |
| 25 mM | 0.0371 mL | 0.1854 mL | 0.3707 mL | 0.9269 mL | |
| 30 mM | 0.0309 mL | 0.1545 mL | 0.3090 mL | 0.7724 mL | |
| 40 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5793 mL | |
| 50 mM | 0.0185 mL | 0.0927 mL | 0.1854 mL | 0.4634 mL | |
| 60 mM | 0.0154 mL | 0.0772 mL | 0.1545 mL | 0.3862 mL | |
| 80 mM | 0.0116 mL | 0.0579 mL | 0.1159 mL | 0.2896 mL |
TEC 4 関連分類
HY-176071 関連分類
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