TRPC5-IN-4
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2762315-39-7
- 分子式: C18H11ClF4N4O3
- 分子量:442.75
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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TRPC5 14.07 nM (IC50) |
TRPC4 65 nM (IC50) |
TRPC5-IN-4 (compound 16 g) (0.003-3 μM; 0-1000 seconds) significantly changes intracellular Ca2+ concentration in TRPC4- and TRPC5-HEK293 cells in a dose-dependent manner, and shows very weak inhibitory activity on the TRPC3 channel, no inhibitory effect on TRPC6 and TRPC7 channels[1].
TRPC5-IN-4 (1 and 10 μM; 24 hours) does not reduce the liver and kidney cells viability[1].
TRPC5-IN-4 (0.1, 0.3, 1, 3 μM; 30 minutes) concentration-dependently reduces the PS-induced podocyte rearrangement in MPC5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultured hepatocytes and MPC5 cells[1]
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Concentration:1 and 10 μM
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Incubation Time:24 hours
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Result:Did not reduce the cell viability, suggesting that TRPC5-IN-4 was unlikely to damage the cellular component of liver and kidney.
化学情報
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CAS 番号 2762315-39-7
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分子量 442.75
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分子式 C18H11ClF4N4O3
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SMILES
O=C1NC(C(N2CCC3=C(N=CN=C3OC4=C(C=C(C=C4)F)C(F)(F)F)C2)=C1Cl)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TRPC5-IN-4 関連分類
HY-144429 関連分類
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