UMK57
Based on 1 Customer Validation
UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors.
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- 純度: 99.51%
- CAS 番号: 342595-74-8
- 分子式: C17H17N3S
- 分子量:295.40
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Kif2c/MCAK |
UMK57 (100 nM; 1-72 h) reduces anaphase lagging chromosome rates in SW620 cells acutely[1].
UMK57 (100 nM; 1-72 h) selectively increases the levels of Aurora kinase A and TPX2 on mitotic spindles without altering Aurora kinase A activation status in SW620 cells[1].
UMK57 specifically potentiates MCAK-mediated microtubule depolymerization in vitro without inhibiting kinesin ATPase activity[2].
UMK57 (0.1-50 μM; 3 days) inhibits U2OS cell proliferation in a dose-dependent manner[2].
UMK57 (100 nM; <1h) suppresses chromosome mis-segregation in U2OS, HeLa, and SW-620 CIN cancer cells[2].
UMK57 (100 nM; 1 h) reduces metaphase k-MT attachment stability in U2OS cells in an MCAK-dependent manner, with no effect on prometaphase k-MT stability initially, but induces reversible hyper-stabilization of prometaphase k-MTs after extended continuous treatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells
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Concentration:0.1; 0.5; 1; 5; 20; 50 μM
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Incubation Time:3 days
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Result:Inhibited cell proliferation of U2OS cells in a dose-dependent manner.
化学情報
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CAS 番号 342595-74-8
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性状 Solid
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分子量 295.40
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分子式 C17H17N3S
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Color Off-white to light yellow
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SMILES
CC1=CC=C(C=C1)C2=CSC3=NC=NC(N4CCCC4)=C32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
Ethanol : 6.67 mg/mL (22.58 mM; Need ultrasonic)
DMSO : 2 mg/mL (6.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kucharski TJ, et al. An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity. Cell Rep. 2025;44(2):115317. [Content Brief]
[2]. Orr B, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 3.3852 mL | 16.9262 mL | 33.8524 mL | 84.6310 mL |
| 5 mM | 0.6770 mL | 3.3852 mL | 6.7705 mL | 16.9262 mL | |
| Ethanol | 10 mM | 0.3385 mL | 1.6926 mL | 3.3852 mL | 8.4631 mL |
| 15 mM | 0.2257 mL | 1.1284 mL | 2.2568 mL | 5.6421 mL | |
| 20 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL | 4.2316 mL |
UMK57 関連分類
HY-122236 関連分類
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