Alcaftadine
Based on 1 publication(s) in Google Scholar
Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects.
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- Purity: 98.37%
- CAS No.: 147084-10-4
- 화학식: C19H21N3O
- 분자량:307.39
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Alcaftadine
MoreAll Histamine Receptor Isoforms
More
Biological Activity
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H1 Receptor |
H2 Receptor |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 147084-10-4
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Appearance Solid
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분자량 307.39
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화학식 C19H21N3O
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Color Light yellow to yellow
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SMILES
O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4
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Synonyms
R89674
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543
용액&용해도
DMSO : ≥ 40 mg/mL (130.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90. [Content Brief]
[2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2532 mL | 16.2660 mL | 32.5320 mL | 81.3299 mL |
| 5 mM | 0.6506 mL | 3.2532 mL | 6.5064 mL | 16.2660 mL | |
| 10 mM | 0.3253 mL | 1.6266 mL | 3.2532 mL | 8.1330 mL | |
| 15 mM | 0.2169 mL | 1.0844 mL | 2.1688 mL | 5.4220 mL | |
| 20 mM | 0.1627 mL | 0.8133 mL | 1.6266 mL | 4.0665 mL | |
| 25 mM | 0.1301 mL | 0.6506 mL | 1.3013 mL | 3.2532 mL | |
| 30 mM | 0.1084 mL | 0.5422 mL | 1.0844 mL | 2.7110 mL | |
| 40 mM | 0.0813 mL | 0.4066 mL | 0.8133 mL | 2.0332 mL | |
| 50 mM | 0.0651 mL | 0.3253 mL | 0.6506 mL | 1.6266 mL | |
| 60 mM | 0.0542 mL | 0.2711 mL | 0.5422 mL | 1.3555 mL | |
| 80 mM | 0.0407 mL | 0.2033 mL | 0.4066 mL | 1.0166 mL | |
| 100 mM | 0.0325 mL | 0.1627 mL | 0.3253 mL | 0.8133 mL |
Alcaftadine Related Classifications
HY-17039 Related Classifications
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