Cat. No.: HY-12220

MM-102

(Synonyms: HMTase Inhibitor IX)

4 Cited Publications

고객리뷰

Based on 4 publication(s) in Google Scholar

MM-102 (HMTase Inhibitor IX) is a cell-permeable and tightly binding inhibitor of MLL1-WDR5 interaction (IC₅₀=2.4 nM). MM-102 can specifically inhibit the growth and induce apoptosis of leukemia cells containing MLL1 fusion protein, and reduce renal fibrosis and inflammation in mice with ischemia-reperfusion injury. In addition, MM-102 also acts as an H3K4 histone methyltransferase inhibitor to improve the development of porcine somatic cell nuclear transfer (SCNT) embryos.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.09%
CAS No.: 1417329-24-8
화학식: C₃₅H₄₉F₂N₇O₄
분자량:669.80

보관:

Sealed storage, away from moisture and light, under nitrogen.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

MM-102 Chemical Structure

CAS No.: 1417329-24-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All NF-κB Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	37.8 μM Compound: MM-102	Growth inhibition of human K562 cells after 7 days by MTS assay Growth inhibition of human K562 cells after 7 days by MTS assay	[PMID: 27598236]
K562	IC₅₀	37.8 μM Compound: MM-102	Antiproliferative activity against human K562 cells harboring BCR-ABL assessed as inhibition of cell viability after 72 hrs by CCK8-based colorimetric assay Antiproliferative activity against human K562 cells harboring BCR-ABL assessed as inhibition of cell viability after 72 hrs by CCK8-based colorimetric assay	[PMID: 27720555]
MV4-11	IC₅₀	20.7 μM Compound: MM-102	Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein after 72 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein after 72 hrs by CCK8 assay	[PMID: 27598236]
MV4-11	IC₅₀	20.7 μM Compound: MM-102	Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 assessed as inhibition of cell viability after 72 hrs by CCK8-based colorimetric assay Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 assessed as inhibition of cell viability after 72 hrs by CCK8-based colorimetric assay	[PMID: 27720555]
MV4-11	IC₅₀	25 μM Compound: MM-102	Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein by CellTiter-Glo assay Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein by CellTiter-Glo assay	[PMID: 27598236]
MV4-11	IC₅₀	25 μM Compound: MM-102	Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 after 7 days by CellTiter-Glo luminescent cell viability Assay Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 after 7 days by CellTiter-Glo luminescent cell viability Assay	[PMID: 27720555]

In Vitro

MM-102 (40 µM; 4 d) induces growth arrest and cell death in MLL1-AF9-transformed mouse leukemia cells specifically in leukemia cells harboring the MLL1 translocation, but does not interfere with the growth of normal bone marrow^[2].
MM-102 (2, 10, and 50 µM) disrupts the association of WDR5 and RbBP5 with GSTMLL1 in a concentration-dependent manner. The association of WDR5 with MLL1 is mildly disrupted at 2 µM, moderately disrupts at 10 µM, and completely disrupts at 50 µM^[2].
MM-102 specifically inhibits the methyltransferase activity of the MLL1 complex with an IC₅₀ value of 0.32 µM^[2].
MM-102 (50 µM; 48 h) can significantly inhibit the proliferation, migration and chemoresistance of TFK1 and RBE cells^[3].
MM-102 (50 µM; 1 h) not only significantly reduces the expression of MLL1, WDR5 and H3K4me3 in TGF-b1-stimulated NRK-49F cells, but also inhibits the expression of p16INK4a^[4].
MM-102 (50-100 μM; 48 h) enhances the developmental competence of porcine SCNT embryos and improves the expression pattern of key genes in SCNT embryo development^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

TFK1 and RBE cells
Concentration:

50 µM
Incubation Time:

48 h
Result:

Inhibited the expression of ABCB1, but had no effect on the expression of MBD2 and WDR5.

In Vivo

MM-102 (15 mg/kg; i.p.; once daily for 7 days) inhibits tumor progression in primary CCA model mice^[3].
MM-102 (15 mg/kg; i.p.; once daily for 7 days) inhibits p16INK4a gene expression in IRI mice and reduces renal fibrosis and renal inflammation in IRI mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ischemia-reperfusion injury in mice^[4]
Dosage:

15 mg/kg
Administration:

i.p.; Once daily for 7 days
Result:

Inhibited a-SMA protein expression.
Inhibited p-NF-kB (p65), IL-1b, TNF-a, and IL-6 mRNA expression.

Chemical Information

CAS No. 1417329-24-8
Appearance Solid
분자량 669.80
화학식 C₃₅H₄₉F₂N₇O₄
Color White to off-white
SMILES

O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Synonyms

HMTase Inhibitor IX
선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Publications (4)

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Cell Death Dis

Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. [Abstract]

2022 Sep 6;13(9):770. PMID: 36068197
Acta Pharmacol Sin

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. [Abstract]

2022 Feb;43(2):457-469. PMID: 33850273
Proc Natl Acad Sci U S A

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer. [Abstract]

2019 Feb 19;116(8):2961-2966. PMID: 30718431
J Mol Endocrinol

Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility. [Abstract]

2021 Jan;66(1):45-57. PMID: 33151904

용액&용해도

In Vitro:

DMSO : 125 mg/mL (186.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4930 mL

7.4649 mL

14.9298 mL

5 mM

0.2986 mL

1.4930 mL

2.9860 mL

10 mM

0.1493 mL

0.7465 mL

1.4930 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013, 135(2), 669-682. [Content Brief]

[2]. Townsend E C. Development of a Novel Inhibitor to the Conserved, Developmental Regulator, WDR5, for Treatment of Acute Leukemia[D]. , 2012.

[3]. Wang D, et al. MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5[J]. Journal of Experimental & Clinical Cancer Research, 2024, 43(1): 272. [Content Brief]

[4]. Hara D, et al. Inhibition of H3K4 Trimethylation Ameliorates Peritoneal Fibrosis and Senescence: FR-PO456[J]. Journal of the American Society of Nephrology, 2022, 33(11S): 447-448. [Content Brief]

[5]. Zhang Z, et al. Down-regulation of H3K4me3 by MM-102 facilitates epigenetic reprogramming of porcine somatic cell nuclear transfer embryos[J]. Cellular Physiology and Biochemistry, 2018, 45(4): 1529-1540. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4930 mL	7.4649 mL	14.9298 mL	37.3246 mL
	5 mM	0.2986 mL	1.4930 mL	2.9860 mL	7.4649 mL
	10 mM	0.1493 mL	0.7465 mL	1.4930 mL	3.7325 mL
	15 mM	0.0995 mL	0.4977 mL	0.9953 mL	2.4883 mL
	20 mM	0.0746 mL	0.3732 mL	0.7465 mL	1.8662 mL
	25 mM	0.0597 mL	0.2986 mL	0.5972 mL	1.4930 mL
	30 mM	0.0498 mL	0.2488 mL	0.4977 mL	1.2442 mL
	40 mM	0.0373 mL	0.1866 mL	0.3732 mL	0.9331 mL
	50 mM	0.0299 mL	0.1493 mL	0.2986 mL	0.7465 mL
	60 mM	0.0249 mL	0.1244 mL	0.2488 mL	0.6221 mL
	80 mM	0.0187 mL	0.0933 mL	0.1866 mL	0.4666 mL
	100 mM	0.0149 mL	0.0746 mL	0.1493 mL	0.3732 mL

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MM-102

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MM-102

All NF-κB Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (4)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

MM-102

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MM-102

All NF-κB Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (4)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

MM-102 Related Classifications

HY-12220 Related Classifications