Arimoclomol
Based on 7 publication(s) in Google Scholar
Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C. Arimoclomol can cross the blood-brain barrier and can be used in research on Niemann-Pick disease type C.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.83%
- CAS No.: 289893-25-0
- 화학식: C14H20ClN3O3
- 분자량:313.78
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Publications Citing Use of MedChemExpress (MCE) Arimoclomol
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Customer Validation & Images
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ELISA
Biological Activity
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HSP |
In the SOD1-G93A mouse model of amyotrophic lateral sclerosis, arimoclomol can delay muscle denervation[2].
Arimoclomol has been used in preclinical studies for neurodegenerative lysosomal storage diseases, such as Niemann-Pick disease type C (NPC), and has shown improvement in the core pathological lesions of central nervous system (CNS) involvement in Gaucher disease (GD2, GD3)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats weighing 240 to 270 g[1]
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Dosage:20 mg/kg
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Administration:Administered intragastrically, for 5 days
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Result:Had a protective effect against CCK-induced acute pancreatitis.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 289893-25-0
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Appearance Solid
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분자량 313.78
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화학식 C14H20ClN3O3
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Color Off-white to yellow
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SMILES
Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2
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Synonyms
BRX-220 free base
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [Abstract]2026 May 2;23(1):206. PMID: 42069589 -
J Neurochem
Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy. [Abstract]2026 Jun;170(6):e70493. PMID: 42283221 -
Exp Eye Res
4-HNE induces proinflammatory cytokines of human retinal pigment epithelial cells by promoting extracellular efflux of HSP70. [Abstract]2019 Nov;188:107792. PMID: 31499034
Arimoclomol purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov;188:107792. [Abstract]
Western blot was used to detect the expression of HSP70 in ARPE-19 cells stimulated by Arimoclomol maleate (10 μM) for 24 h.
Arimoclomol purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov;188:107792. [Abstract]
ARPE-19 cells were simultaneously treated with 4-HNE and Arimoclomol (10 μM) for 24 h, then IL-1β levels in supernatant of ARPE-19 cells were detected by corresponding ELISA kit.
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Int J Mol Sci
Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function. [Abstract]2024 May 16;25(10):5417. PMID: 38791456
Arimoclomol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 May 16;25(10):5417. [Abstract]
Representative western blotting showing the effect of Arimoclomol maleate (Ari: 300 μM) treatments on protein expression in PS1 (PS1KO) and PS2 KO (PS2KO) mouse embryonic fibroblasts (MEFs).
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용액&용해도
DMSO : 25 mg/mL (79.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]
[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1869 mL | 15.9347 mL | 31.8695 mL | 79.6737 mL |
| 5 mM | 0.6374 mL | 3.1869 mL | 6.3739 mL | 15.9347 mL | |
| 10 mM | 0.3187 mL | 1.5935 mL | 3.1869 mL | 7.9674 mL | |
| 15 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL | 5.3116 mL | |
| 20 mM | 0.1593 mL | 0.7967 mL | 1.5935 mL | 3.9837 mL | |
| 25 mM | 0.1275 mL | 0.6374 mL | 1.2748 mL | 3.1869 mL | |
| 30 mM | 0.1062 mL | 0.5312 mL | 1.0623 mL | 2.6558 mL | |
| 40 mM | 0.0797 mL | 0.3984 mL | 0.7967 mL | 1.9918 mL | |
| 50 mM | 0.0637 mL | 0.3187 mL | 0.6374 mL | 1.5935 mL | |
| 60 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3279 mL |
Arimoclomol Related Classifications
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