country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182439

Copy Link Print Information

AZD3778

AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC₅₀ values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 485391-80-8
화학식: C₂₄H₂₉Cl₂N₃O₄S
분자량:526.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZD3778 Chemical Structure

CAS No.: 485391-80-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CCR3

8.1 nM (IC₅₀)

Human H₁ Receptor

40 nM (IC₅₀)

All Histamine Receptor Isoforms :

All CCR Isoforms :

In Vitro

AZD3778 is a CCR3 and histamine H1 receptor inhibitor, with IC₅₀ values of 8.1 nM and 40 nM against human targets, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 485391-80-8
분자량 526.48
화학식 C₂₄H₂₉Cl₂N₃O₄S
SMILES

O=C(N1CCC(CC1)N2CCC(CC2)OC3=CC=C(C(Cl)=C3)Cl)NS(=O)(C4=CC=C(C)C=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham.

[2]. Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AZD3778

All Histamine Receptor Isoforms

All CCR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AZD3778 Related Classifications

HY-182439 Related Classifications