Ceftolozane
Based on 2 publication(s) in Google Scholar
Ceftolozane is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane can be used in studies related to bacterial infections.
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- CAS No.: 689293-68-3
- 화학식: C23H30N12O8S2
- 분자량:666.69
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ceftolozane
MoreAll Antibiotic Isoforms
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Biological Activity
제품 설명
In Vitro
Ceftolozane (0.5-50 μg/mL; 1-7 days) is stable in human K2EDTA plasma for at least 7 days at 6 °C and −20 °C, shows acceptable stability (≤15% decay) for 71.2 h at 23 °C and 5.6 h at 40 °C, with comparable stability at 0.5 μg/mL and 50 μg/mL concentrations[2].
Ceftolozane (50 μg/mL; 1-7 days) is stable in human K2EDTA full blood for at least 7 days at 6 °C, and shows acceptable stability (≤15% decay) for 121.8 h at 23 °C, with stability comparable to plasma samples[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 689293-68-3
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Appearance Solid
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분자량 666.69
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화학식 C23H30N12O8S2
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Color White to off-white
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SMILES
CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
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Synonyms
CXA-101 free base; FR264205 free base
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. [Abstract]2024 Dec 31;20(12):e1012783. PMID: 39739989 -
Microbiol Spectr
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae. [Abstract]2023 Jun 15;11(3):e0069223. PMID: 37093051
용액&용해도
In Vitro:
DMSO : 24 mg/mL (36.00 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4999 mL | 7.4997 mL | 14.9995 mL | 37.4987 mL |
| 5 mM | 0.3000 mL | 1.4999 mL | 2.9999 mL | 7.4997 mL | |
| 10 mM | 0.1500 mL | 0.7500 mL | 1.4999 mL | 3.7499 mL | |
| 15 mM | 0.1000 mL | 0.5000 mL | 1.0000 mL | 2.4999 mL | |
| 20 mM | 0.0750 mL | 0.3750 mL | 0.7500 mL | 1.8749 mL | |
| 25 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.4999 mL | |
| 30 mM | 0.0500 mL | 0.2500 mL | 0.5000 mL | 1.2500 mL |
Ceftolozane Related Classifications
HY-19806 Related Classifications
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Keywords
- Ceftolozane
- 689293-68-3
- CXA-101
- FR264205
- CXA101
- CXA 101
- FR 264205
- FR-264205
- Bacterial
- Antibiotic
- gram-negative pathogens
- bacterial infection
- complicated intra-abdominal infections
- cephalosporin β-lactam
- complicated urinary tract infections
- extended spectrum β-lactamases
- acute pyelonephritis
- carbapenemases
- Klebsiella pneumoniae
- nosocomial pneumonia
- Inhibitor
- inhibitor
- inhibit