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Cat. No.: HY-122223

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EPZ030456

EPZ030456 is a potent and selective SMYD3 inhibitor with an IC₅₀ of 48 nM. EPZ030456 can be used for cancer research.

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CAS No.: 1808011-23-5
화학식: C₂₈H₃₄ClN₅O₄S
분자량:572.12

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

EPZ030456 Chemical Structure

CAS No.: 1808011-23-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
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Calculators
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Bioz

Biological Activity

제품 설명

EPZ030456 is a potent and selective SMYD3 inhibitor with an IC₅₀ of 48 nM. EPZ030456 can be used for cancer research^[1].

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	48 nM Compound: EPZ030456	Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by incubation for 24 hrs at 37 degC by Western blot analysis Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by incubation for 24 hrs at 37 degC by Western blot analysis	[PMID: 26985287]

Chemical Information

CAS No. 1808011-23-5
분자량 572.12
화학식 C₂₈H₃₄ClN₅O₄S
SMILES

O=S(N1[C@]2([H])C[C@H](C[C@@]1([H])CC2)NC(C3=C(Cl)C=C(NC(C4)=O)C4=C3)=O)(N5CCC(CC5)NCC6=CC=CC=C6)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lorna H Mitchell, et al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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EPZ030456

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EPZ030456 Related Classifications

HY-122223 Related Classifications