S1PR1 - sphingosine-1-phosphate receptor 1 Gene

Also Known as EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1901

About S1PR1

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:101,236,899-101,242,313 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 18 paralogues. Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues.

Summary

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

S1PR1 Products (9)

mRNA Protein Name
NR_174347.1
XR_007095678.1
NR_174349.1
NR_174346.1
NR_174348.1
NM_001320730.2 NP_001307659.1 sphingosine 1-phosphate receptor 1
NR_174350.1
NR_174345.1
NM_001400.5 NP_001391.2 sphingosine 1-phosphate receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
24851274 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16525420 GOA
enables sphingosine-1-phosphate receptor activity IDA
IDA: Inferred from direct assay
22344443 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell migration IDA
IDA: Inferred from direct assay
37039481 GOA
involved in sphingosine-1-phosphate receptor signaling pathway IDA
IDA: Inferred from direct assay
22344443 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22344443 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 311)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 1

  • S1P receptor 1

  • S1P receptor Edg-1

  • endothelial differentiation G-protein coupled receptor 1

  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

  • sphingosine 1-phosphate receptor EDG1

  • sphingosine 1-phosphate receptor Edg-1

S1PR1 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P81494 S1P1/EDG1 Antibody (YA1239) IHC-P Human
HY-P81494A S1P1/EDG1 Antibody (YA1239)(PBS only) IHC-P Human
HY-P84177 S1P1/EDG1 Antibody (YA3874) WB, IHC-P, FC, ELISA Human
HY-P84177A S1P1/EDG1 Antibody (YA3874)(PBS only) WB, IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Relapsing-Remitting Multiple Sclerosis

  • Relapsing-Remitting Ms

  • Relapsing Remitting Multiple Sclerosis

  • Multiple Sclerosis, Relapsing-Remitting

  • Rrms

  • Multiple Sclerosis Relapsing-Remitting
Demyelinating Disease

  • Demyelinating Diseases

  • Demyelinating Disorder
Autoimmune Disease Of Central Nervous System
Herpes Zoster Oticus

  • Nervus Intermedius Neuralgia

  • Geniculate Herpes Zoster

  • Geniculate Neuralgia

  • Ramsay Hunt Syndrome Type 2

  • Herpes Zoster Auricularis

  • Herpetic Geniculate Ganglionitis

  • Ramsay Hunt Syndrome Type Ii

  • Ramsey Hunt Syndrome

  • Facial Nerve Palsy Due To Vzv

  • Facial Nerve Palsy Due To Herpes Zoster Infection

  • Facial Nerve Paralysis Due To Vzv

  • Hunt Syndrome

  • Hunt'S Syndrome

  • Ramsay Hunt Syndrome

  • Myoclonus And Ataxia
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Second-Degree Atrioventricular Block

  • Second-Degree Heart Block

  • Second Degree Atrioventricular Block

  • Second Degree Atrioventricular Heart Block

  • Second Degree Heart Block

  • Incomplete Atrioventricular Block, Second Degree Nos

  • Second-Degree Block, Type 1 And 2

  • Atrioventricular Block, Type 1 And 2

  • Second Degree Incomplete Atrioventricular Block

  • Av - [Atrioventricular] Block 2nd
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Progressive Multifocal Leukoencephalopathy

  • Pml

  • Leukoencephalopathy, Progressive Multifocal

  • Progressive Multifocal Leukoencephalitis

  • Leukoencephalopathy Progressive Multifocal

  • Pml - [Progressive Multifocal Leukoencephalopathy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12288 Ozanimod Agonist 99.98% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12288A Ozanimod hydrochloride Modulator 98.10% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명 효과
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
HY-132847 Vibozilimod Agonist 99.52% Phase 2
HY-119245 Udifitimod Modulator / Phase 2
HY-115831 SAR247799 Agonist 99.38% Phase 1
HY-14976 CS-0777 Modulator / Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-W008947 SEW​2871 Agonist 99.88% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-136578 RP101988 Agonist 98.80% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-158417 KSI-6666 Antagonist 96.15% Unkown
HY-136576 RP101075 Agonist 99.19% Unkown
HY-109038 Mocravimod Modulator 98.39% Yes
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist 98.0% Unkown
HY-14433 PF-462991 Agonist / Unkown
HY-120615 BMS-520 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown
HY-183578 TYY-31 Agonist / Unkown
HY-181875 S1PR1/S1PR5 agonist-1 Inhibitor / Unkown
HY-178491 S1PR1 agonist 3 Agonist / Unkown
HY-108492 TC-SP 14 Agonist / Unkown
HY-182626 CS1P1 Antagonist / Unkown
HY-14402 AMG 369 Agonist / Unkown
HY-182375 (R)-SLB1122168 free base Inhibitor / Unkown
HY-182960 KRP-203 monophosphate / Unkown
HY-18334 GSK-2262167 sodium Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris S1PR1 VGNC VGNC:45836
Mus musculus S1PR1 MGD MGI:1096355
Rattus norvegicus S1PR1 RGD RGD:61958
Macaca mulatta S1PR1 VGNC VGNC:100129
Bos taurus S1PR1 VGNC VGNC:34252
Felis catus S1PR1 VGNC VGNC:64845
Others S1PR1 NCBI